Murepavadin (POL7080) is a highly potent, specific, macrocycle Pseudomonas antibiotic for the treatment of bacterial infections caused by Pseudomonas aeruginosa.
CAT# | R1900 |
Chemical Structure | |
CAS | 944252-63-5 |
Chemical Name | (3R,9S,12S,15S,18S,21S,24S,27R,30S,33S,36S,39S,42S,45S)-15,18,24,27,33-pentakis(2-aminoethyl)-30-(3-aminopropyl)-36-[(2S)-butan-2-yl]-42-[(1R)-1-hydroxyethyl]-9-(hydroxymethyl)-21,39-bis(1H-indol-3-ylmethyl)-12-methyl-1,7,10,13,16,19,22,25,28,31,34,37,40,43-tetradecazatricyclo[43.3.0.03,7]octatetracontane-2,8,11,14,17,20,23,26,29,32,35,38,41,44-tetradecone |
M.F/Formula | C73H112N22O16 |
M.W/Mr. | 1553.8 |
Sequence | cyclo[Ala-Ser-D-Pro-Pro-Thr-Trp-Ile-Dab-Orn-D-Dab-Dab-Trp-Dab-Dab] |
Application | Bacterial infections |
Activity | Antibiotic |
Biological Activity | Pathogen specific antimicrobial peptidomimetic with a novel, non-lytic mechanism of action, being the first in class of outer membrane protein targeting antibiotics, displaying a potent in vitro activity including carbapenemase-producing and colistin-resistant P. aeruginosa |
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