TRV-120027

Name: TRV-120027
Brand: Creative Peptides
SKU: R1867
Availability: MadeToOrder

TRV-120027 is an investigational drug designed as a selective, orally bioavailable, small molecule that inhibits the activity of the TRPC5 ion channel.

Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).

CAT No: R1867

CAS No: 1234510-46-3

Synonyms/Alias: TRV-120027;1234510-46-3;trv027;TRV120027;TRV-027;UNII-J1J4P3PQZD;TRV 027;J1J4P3PQZD;TRV 120027;D-Alanine, N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-;Sar-val-tyr-ile-his-pro-d-ala-oh;(2R)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid;Sar-Arg-Val-Tyr-Ile-His-Pro-Ala;GTPL6902;CHEMBL4297447;TRV 027 [WHO-DD];GLXC-27746;HY-P2141;AKOS040764215;DB12199;NMeGly-Arg-Val-Tyr-Ile-His-Pro-DAla;DA-58776;CS-0109050;NS00073768;G17966;Q27281029;

Chemical Name: (2R)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid

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Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C43H67N13O10
M.W/Mr.	926.1
Sequence	One Letter Code:GRVYIHPA Three Letter Code:H-Sar-Arg-Val-Tyr-Ile-His-Pro-D-Ala-OH
Application	TRV120027 has been used in trials studying the treatment of Heart Failure and Kidney Disease.

Long-term Storage Conditions	10 mM in DMSO
Shipping Condition	+20°C (International: -20°C)
InChI	InChI=1S/C43H67N13O10/c1-7-24(4)35(40(63)53-31(19-27-20-47-22-49-27)41(64)56-17-9-11-32(56)38(61)50-25(5)42(65)66)55-37(60)30(18-26-12-14-28(57)15-13-26)52-39(62)34(23(2)3)54-36(59)29(51-33(58)21-46-6)10-8-16-48-43(44)45/h12-15,20,22-25,29-32,34-35,46,57H,7-11,16-19,21H2,1-6H3,(H,47,49)(H,50,61)(H,51,58)(H,52,62)(H,53,63)(H,54,59)(H,55,60)(H,65,66)(H4,44,45,48)/t24-,25+,29-,30-,31-,32-,34-,35-/m0/s1
InChI Key	XIEWFECSPPTVQN-KMIMAYJXSA-N
Canonical SMILES	CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(C)C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)CNC
Isomeric SMILES	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
References	[1]. Boerrigter G, et al. TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure.Circ Heart Fail. 2012 Sep 1;5(5):627-34. Epub 2012 Aug 13. [2]. Liu CH, et al. Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.Nat Commun. 2017 Feb 9; 8:14335.

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2. Constitutive and inflammation-dependent antimicrobial peptides produced by epithelium are differentially processed and inactivated by the commensal Finegoldia magna and the pathogen Streptococcus pyogenes

3. Quantitative Analysis of Ligands Effects on Bioefficacy of Nanoemulsion encapsulating Depigmenting Active

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