Dermorphin

Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Dermorphin(CAS 77614-16-5)

CAT No: R1324

CAS No:77614-16-5

Synonyms/Alias:Dermorphin;77614-16-5;H-Tyr-D-ala-phe-gly-tyr-pro-ser-NH2;(2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide;Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide;UNII-2SEC01B703;DERMORPHIN ACETATE;2SEC01B703;Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2;CHEMBL278789;DTXSID40228281;L-SERINAMIDE, L-TYROSYL-D-ALANYL-L-PHENYLALANYLGLYCYL-L-TYROSYL-L-PROLYL-;(2S)-N-((2S)-1-amino-3-hydroxy-1-oxopropan-2-yl)-1-((2S)-2-((2-(((2S)-2-(((2R)-2-(((2S)-2-amino-3-(4-hydroxyphenyl)propanoyl)amino)propanoyl)amino)-3-phenylpropanoyl)amino)acetyl)amino)-3-(4-hydroxyphenyl)propanoyl)pyrrolidine-2-carboxamide;YAFGYPS-NH2;SCHEMBL237169;Tyr-Ala-Phe-Gly-Tyr-Pro-Ser;DTXCID60150772;CHEBI:177767;EX-A7078;HY-P0244;BDBM50059841;Tyr-DAla-Phe-Gly-Tyr-Pro-Ser-NH2;DA-62786;FD108711;MS-31482;NS00096954;C20030;G12242;Q1771654;(S)-1-[(S)-2-[2-((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-acetylamino]-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carboxylic acid ((S)-1-carbamoyl-2-hydroxy-ethyl)-amide;(S)-N-((S)-1-amino-3-hydroxy-1-oxopropan-2-yl)-1-((2S,8S,11R,14S)-14-amino-8-benzyl-2-(4-hydroxybenzyl)-15-(4-hydroxyphenyl)-11-methyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecane)pyrrolidine-2-carboxamide;1-[2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-acetylamino]-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carboxylic acid (1-carbamoyl-2-hydroxy-ethyl)-amide;1-[2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-acetylamino]-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carboxylic acid (1-carbamoyl-2-hydroxy-ethyl)-amide (Dermorphin);1-[2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-acetylamino]-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carboxylic acid (1-carbamoyl-2-hydroxy-ethyl)-amide(Dermorphin);Dermorphin;1-[2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-acetylamino]-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carboxylic acid (1-carbamoyl-2-hydroxy-ethyl)-amide;

Chemical Name:(2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2- [[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl] amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl) propanoyl]pyrrolidine-2-carboxamide

Custom Peptide Synthesis
cGMP Peptide
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  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C40H50N8O10
M.W/Mr.
802.9
Sequence
One Letter Code:YAFGYPS
Three Letter Code:H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2
Appearance
White to off white powder
Purity
> 96%
Length
8
Long-term Storage Conditions
Slightly soluble in water, 10 mM in H2O
Shipping Condition
Wet ice
InChI
InChI=1S/C40H50N8O10/c1-23(44-37(55)29(41)18-25-9-13-27(50)14-10-25)36(54)46-30(19-24-6-3-2-4-7-24)38(56)43-21-34(52)45-31(20-26-11-15-28(51)16-12-26)40(58)48-17-5-8-33(48)39(57)47-32(22-49)35(42)53/h2-4,6-7,9-16,23,29-33,49-51H,5,8,17-22,41H2,1H3,(H2,42,53)(H,43,56)(H,44,55)(H,45,52)(H,46,54)(H,47,57)/t23-,29+,30+,31+,32+,33+/m1/s1
InChI Key
FHZPGIUBXYVUOY-VWGYHWLBSA-N
Canonical SMILES
CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NCC(=O)NC(CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CO)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)O)N

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