P110 is a peptide designed to modulate dynamin-related protein interactions by mimicking specific recognition motifs. Hydrophobic and charged residues contribute to folding and target-binding fidelity. Researchers assess its conformational preferences and binding thermodynamics. Applications include mitochondrial-dynamics studies, motif-function characterization, and PPI-inhibition modeling.
CAT No: R2808
P110, a synthetic peptide derived from the mitochondrial fission protein Drp1, represents a significant advancement in the field of carbohydrate compound research. Engineered to modulate mitochondrial dynamics, P110 is designed to selectively inhibit the interaction between Drp1 and its receptor Fis1, thereby influencing mitochondrial fission processes. Its unique mechanism of action has made it an invaluable tool in laboratory investigations aimed at elucidating the intricate balance between mitochondrial fission and fusion, which is central to cellular homeostasis and energy metabolism. The stability and specificity of P110 allow researchers to explore mitochondrial behavior under various experimental conditions, providing insights into the cellular responses to metabolic stress, oxidative damage, and other perturbations that affect mitochondrial function. As a research reagent, P110 is favored for its targeted approach, minimizing off-target effects and enabling precise modulation of mitochondrial dynamics in a range of cell types and model systems.
Mitochondrial Dynamics Research: In the context of mitochondrial biology, P110 is widely utilized to dissect the molecular mechanisms governing mitochondrial fission and fusion. By selectively inhibiting Drp1-Fis1 interactions, the peptide enables researchers to investigate the consequences of altered mitochondrial morphology on cellular metabolism, apoptosis, and reactive oxygen species production. This targeted modulation is particularly valuable for studying the adaptive responses of mitochondria to changes in nutrient availability, cellular energy demands, and environmental stressors. Insights gained from these studies contribute to a deeper understanding of mitochondrial quality control and its implications for cellular health and disease.
Neurodegeneration Models: P110 has been extensively adopted in studies modeling neurodegenerative processes, where mitochondrial dysfunction is a hallmark feature. By modulating mitochondrial fission, the peptide allows for the examination of neuronal survival, synaptic integrity, and axonal transport under conditions that mimic neurodegenerative stress. Researchers utilize P110 to explore the relationship between mitochondrial dynamics and the accumulation of misfolded proteins, synaptic loss, and impaired bioenergetics, thereby advancing the understanding of neuronal vulnerability and resilience in disease-relevant contexts.
Cardiac Stress and Ischemia Studies: In the field of cardiovascular research, P110 serves as a valuable reagent for investigating the role of mitochondrial dynamics in cardiac stress and ischemia-reperfusion injury. Experimental models employing P110 facilitate the analysis of mitochondrial morphology, calcium handling, and oxidative stress in cardiomyocytes subjected to hypoxic or ischemic conditions. The peptide's ability to modulate the fission machinery enables researchers to delineate the contribution of mitochondrial fragmentation to cell death pathways and myocardial recovery, providing a platform for the development of novel cardioprotective strategies.
Metabolic Disease Research: Studies focused on metabolic disorders such as obesity and diabetes increasingly incorporate P110 to probe the link between mitochondrial dynamics and metabolic dysfunction. By altering mitochondrial fission, researchers can assess the impact on insulin signaling, glucose uptake, and lipid metabolism in various cell and tissue models. The use of P110 in these investigations sheds light on the adaptive and maladaptive changes in mitochondrial structure that accompany metabolic stress, offering new perspectives on the cellular basis of metabolic disease progression.
Aging and Cellular Senescence: The peptide is also instrumental in aging research, where mitochondrial fragmentation and dysfunction are closely associated with cellular senescence and age-related decline. By modulating mitochondrial morphology, P110 provides a means to study the effects of altered fission on cellular lifespan, stress resistance, and the accumulation of senescence markers. These studies contribute to the broader understanding of mitochondrial contributions to the aging process and the identification of potential interventions to mitigate age-related cellular deterioration.
In summary, P110 has emerged as a versatile and powerful tool in the study of mitochondrial dynamics across diverse research fields, including neurobiology, cardiology, metabolism, and aging. Its targeted mechanism of action allows for precise interrogation of mitochondrial fission processes, enabling scientists to unravel complex cellular responses to stress, disease, and environmental challenges. As research into mitochondrial biology continues to expand, P110 remains an essential reagent for advancing knowledge and fostering innovation in the exploration of cellular energetics and homeostasis.
4. Store-operated Ca2+ entry sustains the fertilization Ca2+ signal in pig eggs
5. The spatiotemporal control of signalling and trafficking of the GLP-1R
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