SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).
CAT No: R1665
CAS No:125911-68-4
Synonyms/Alias:SAMS Peptide;125911-68-4;SAMSPeptide;BDBM213211;SAMS Peptide trifluoroacetate salt;US9290517, SAMS;EX-A7493;MFCD02682924;AKOS024456537;L-Histidyl-L-Methionyl-L-Arginyl-L-Seryl-L-Alanyl-L-Methionyl-L-Serylglycyl-L-Leucyl-L-Histidyl-L-Leucyl-L-Valyl-L-Lysyl-L-Arginyl-L-Arginine;A11754;Sams peptide (H-His-Met-Arg-Ser-Ala-Met-Ser-Gly-Leu-His-Leu-Val-Lys-Arg-Arg-OH);
SAMS (S-adenosyl-L-methionine sulfonium salt) is a biologically significant compound that plays a central role in methyl group transfer reactions within cellular metabolism. As a derivative of methionine, it functions as a universal methyl donor, facilitating a wide array of methylation processes essential to the regulation of gene expression, protein function, and the biosynthesis of various biomolecules. Its unique sulfonium structure confers high reactivity, making it indispensable in both fundamental research and specialized biochemical applications. SAMS is widely utilized in studies investigating methylation dynamics, enzymatic mechanisms, and metabolic pathways, offering researchers a robust tool to dissect complex biochemical systems and regulatory networks.
Epigenetics Research: In the context of epigenetic studies, SAMS is frequently employed to investigate DNA and histone methylation mechanisms. As the principal methyl donor in methyltransferase-catalyzed reactions, it enables researchers to probe the regulation of gene activity and chromatin structure. By modulating methylation patterns in vitro, investigators can elucidate the roles of specific methyltransferases and explore the reversible nature of epigenetic modifications, thereby advancing the understanding of gene regulation and cellular differentiation.
Enzyme Mechanism Elucidation: SAMS serves as a critical substrate in the biochemical characterization of methyltransferases and related enzymes. Its use in in vitro assays allows for precise monitoring of methyl group transfer to nucleic acids, proteins, lipids, and small molecules. These studies help define substrate specificity, catalytic efficiency, and kinetic parameters, providing insights into enzyme function, inhibition, and potential allosteric regulation. Such mechanistic information is vital for the rational design of modulators and for understanding the biochemical basis of metabolic disorders.
Metabolic Pathway Analysis: The compound is instrumental in mapping methionine and one-carbon metabolism. By tracking the incorporation of methyl groups from SAMS into downstream metabolites, researchers can dissect metabolic flux and regulatory checkpoints within the methionine cycle, transsulfuration pathway, and folate-mediated one-carbon network. These investigations are crucial for unraveling the biochemical underpinnings of nutrient sensing, cellular redox balance, and the interplay between metabolism and epigenetic control.
Analytical Reference Standard: Due to its well-characterized structure and reactivity, SAMS is commonly used as an analytical standard in chromatographic and mass spectrometric assays. It enables the accurate quantification and identification of methylated products, assessment of enzymatic activity, and validation of assay performance. Its inclusion as a reference compound enhances data reliability in both qualitative and quantitative analytical workflows, supporting high-precision biochemical research and method development.
Cellular Function Studies: SAMS is also utilized in cell-based experiments to modulate intracellular methylation capacity and to assess the downstream effects on cellular physiology. By altering methyl donor availability, researchers can investigate the impact on signal transduction, gene expression, and metabolic adaptation. These studies facilitate the exploration of methylation-dependent regulatory mechanisms and their relevance to cellular homeostasis, stress responses, and adaptive processes in diverse biological systems.
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