TC 14012 is an antagonist of CXCR4, which blocks CXCR4-mediated HIV infection with an IC50 value of 19.3 nM. Moreover, TC 14012 (100 µg/ml) inhibits CXCL12-induced phosphorylation of p42/44 MAPK and STAT3 in B cells from patients with chronic lymphocytic leukemia. TC 14012 is also ACKR3 (CXCR7) agonist.
CAT# | R1095 |
CAS | 368874-34-4 |
M.F/Formula | C90H140N34O19S2 |
M.W/Mr. | 2066.43 |
Sequence | RRACYXKXPYRXCR(Disulfide bridge between Cys4 and Cys13, Arg-14 = C-terminal amide, Ala-3 = 3-(2-naphthalenyllalanine), X-6 and X-12 = L-Citrulline, X-8 = D-Citrulline) |
Labeling Target | C-X-C chemokine receptor type 4 (CXCR4) |
Appearance | Crystalline solid |
Purity | >95% |
Activity | Antagonist |
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