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UP_P0C1R7

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: X18077

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
Sequence
GCCSHPACNVNNPHICG
Functions
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This peptide avidly binds AChBP (ACh binding protein) from Bulinus, Lymanea and Aplysia. It potently blocks alpha-3/beta-2 (IC(50)=11 nM). It also inhibits homomeric alpha-7 (IC(50)=27.1 nM) and alpha-6/beta-2 (IC(50)=201 nM) nAChRs. It is inactive on alpha-1/beta-1/delta/epsilon, alpha-2/beta-2, alpha- 3/beta-4 and alpha-4/beta-2 nAChRs.
Source#
Synthetic
Solubility
-20°C

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