Acetyl-Octreotide features an acetylated N-terminus that modulates peptide stability and receptor-interaction studies. Its cyclic core and diverse side chains support investigations of conformational rigidity in solution. Researchers analyze its folding, hydrophobic packing, and charge distribution. Applications span peptide-structure modeling, ligand optimization, and signaling-pathway research.
CAT No: R2430
CAS No:83795-61-3
Synonyms/Alias:Acetyl-Octreotide;83795-61-3;HY-P5085;DA-60734;CS-0676026;(4R,7S,10S,13R,16S,19R)-19-[[(2R)-2-acetamido-3-phenylpropanoyl]amino]-10-(4-aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide;
Acetyl-Octreotide, a synthetic octapeptide analog of somatostatin, is distinguished by its acetylated N-terminus, which enhances its metabolic stability and bioactivity in experimental settings. As a potent modulator of hormone secretion, this compound is widely recognized for its ability to bind with high affinity to somatostatin receptors, particularly subtypes 2 and 5, thereby inhibiting the release of various endocrine and exocrine factors. The unique structure of Acetyl-Octreotide not only confers improved resistance to enzymatic degradation but also provides a valuable tool for researchers aiming to dissect somatostatin-mediated signaling pathways. Its versatility in modulating cellular responses, coupled with its well-characterized receptor interactions, makes it an indispensable resource in the study of neuroendocrine functions, cellular signaling, and peptide-receptor pharmacology.
Endocrine Research: Acetyl-Octreotide serves as a powerful investigative tool in the field of endocrine research, where it is employed to elucidate the regulatory mechanisms of hormone secretion. By mimicking the action of endogenous somatostatin and selectively activating specific receptor subtypes, it allows scientists to study the dynamic control of hormones such as growth hormone, insulin, and glucagon in cultured cell lines and animal models. The application of this analog in in vitro and in vivo experiments provides critical insights into feedback loops, receptor desensitization, and the physiological consequences of somatostatin receptor modulation, thereby advancing the understanding of endocrine system regulation.
Neurobiology Studies: In neurobiology, Acetyl-Octreotide is utilized to probe the role of somatostatinergic signaling in neuronal communication and synaptic plasticity. Its ability to cross biological barriers and maintain activity over extended periods enables detailed mapping of somatostatin receptor distribution and function within the central and peripheral nervous systems. Researchers use this peptide to investigate its effects on neurotransmitter release, neuronal excitability, and neuroprotective mechanisms, contributing to knowledge about neural circuit modulation and the potential implications for neurological disorders.
Cancer Research: The relevance of Acetyl-Octreotide extends to cancer research, particularly in exploring the proliferation and secretory activity of neuroendocrine tumor cells. By binding to somatostatin receptors expressed on tumor cells, it facilitates the study of receptor-mediated inhibition of cell growth and hormone hypersecretion. Experimental models employing this analog help delineate the molecular pathways involved in tumorigenesis, angiogenesis, and apoptosis, offering a platform for evaluating the efficacy of receptor-targeted strategies in preclinical settings.
Signal Transduction Analysis: Scientists leverage Acetyl-Octreotide to dissect intracellular signaling cascades triggered by somatostatin receptor activation. Its stable structure and receptor selectivity allow for precise modulation of downstream effectors such as adenylate cyclase, phospholipase C, and various kinases. Through these studies, researchers can better understand the cross-talk between G protein-coupled receptors and intracellular signaling networks, unraveling the complex mechanisms that govern cellular responses to external stimuli.
Peptide Drug Development: The structural features and pharmacological properties of Acetyl-Octreotide make it a valuable template in the design and optimization of novel peptide-based therapeutics. By serving as a reference compound, it aids medicinal chemists in structure-activity relationship studies, stability enhancement, and receptor subtype selectivity profiling. Its use in preclinical research accelerates the identification of new analogs with improved pharmacodynamic and pharmacokinetic profiles, supporting innovation in the field of peptide drug discovery.
In summary, Acetyl-Octreotide is an essential compound for a broad spectrum of scientific investigations, ranging from basic research in hormone regulation and neurobiology to advanced applications in cancer biology, signal transduction, and peptide drug design. Its unique attributes, including enhanced stability and receptor specificity, empower researchers to explore the multifaceted roles of somatostatin analogs in cellular physiology and disease models. As a research tool, it continues to drive progress in understanding complex biological systems and in the development of next-generation peptide-based therapeutics.
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