Angiopep-2 TFA contains hydrophobic and polar residues arranged to promote receptor interaction and peptide trafficking studies. The sequence assists in modeling membrane affinity, structural adaptability, and ligand-binding properties. Researchers employ it in conformational and biophysical analyses. Its TFA salt improves handling and solubility.
CAT No: R2229
CAS No:906480-05-5
Synonyms/Alias:Angiopep-2 TFA;906480-05-5;SCHEMBL22807671;
Angiopep-2 TFA, a synthetic peptide derived from the Kunitz domain of aprotinin, is widely recognized for its exceptional ability to traverse the blood-brain barrier (BBB) via receptor-mediated transcytosis. This product is characterized by its high affinity for the low-density lipoprotein receptor-related protein-1 (LRP-1), a feature that has made it a valuable molecular tool in neuroscience research and pharmaceutical development. The trifluoroacetate (TFA) salt form ensures stability and solubility, facilitating its integration into various experimental protocols. Its unique sequence and structural properties enable it to function as a robust carrier for targeted delivery applications, particularly in the context of central nervous system (CNS) investigations.
Drug Delivery Systems: Angiopep-2 TFA is extensively utilized in the development of advanced drug delivery systems targeting the brain. By conjugating therapeutic agents, nanoparticles, or imaging probes to this peptide, researchers can achieve enhanced transport across the BBB. The peptide's interaction with LRP-1 receptors on the endothelial cells of the brain capillaries enables receptor-mediated endocytosis and subsequent transcytosis, allowing conjugated molecules to bypass the restrictive nature of the BBB. This mechanism is particularly valuable for delivering chemotherapeutics, neuroprotective agents, or diagnostic compounds to the CNS, addressing longstanding challenges in treating neurological disorders and brain tumors. The use of Angiopep-2 as a vector not only improves the bioavailability of active agents in the brain but also minimizes systemic exposure, thereby reducing potential off-target effects.
Neuroscience Research: In neuroscience research, Angiopep-2 TFA serves as a strategic tool for investigating brain physiology and pathology. By facilitating the delivery of molecular probes or tracers into the brain, it enables detailed mapping of brain regions, receptor distribution, and cellular interactions. Its ability to cross the BBB without disrupting its integrity makes it suitable for longitudinal studies requiring repeated administration of research agents. Moreover, the peptide's compatibility with a variety of payloads, including fluorescent markers and radiolabeled compounds, supports multimodal imaging approaches. These applications contribute to a deeper understanding of CNS function and disease mechanisms, supporting the development of novel therapeutic strategies.
Gene Therapy Vectors: The application of Angiopep-2 TFA in gene therapy research has gained significant traction. By coupling nucleic acids, such as siRNA, antisense oligonucleotides, or plasmids, to this peptide, scientists can enhance the delivery of genetic material to neural tissues. This approach leverages the peptide's receptor-mediated transport capabilities to facilitate efficient transfection of target cells within the brain. As a result, it opens new avenues for studying gene function, modulating gene expression, and evaluating the therapeutic potential of genetic interventions for neurodegenerative diseases and other CNS disorders.
Nanotechnology Platforms: Nanotechnology platforms benefit from the incorporation of Angiopep-2 TFA as a targeting ligand. Functionalizing nanoparticles, liposomes, or dendrimers with this peptide allows for precise navigation across the BBB and targeted delivery to specific brain regions or cell types. This targeted approach increases the therapeutic index of encapsulated drugs or imaging agents, reducing the required dosage and minimizing systemic toxicity. The versatility of Angiopep-2 in nanomedicine extends to the development of multifunctional nanocarriers that combine therapeutic, diagnostic, and monitoring capabilities within a single platform, advancing the field of personalized medicine.
Peptide Engineering and Bioconjugation: The unique properties of Angiopep-2 TFA make it a valuable component in peptide engineering and bioconjugation studies. Researchers exploit its sequence to design novel peptide constructs with enhanced BBB permeability or tailored receptor specificity. Its compatibility with a wide range of chemical modifications enables the creation of customized bioconjugates for specific research objectives. These engineered peptides are instrumental in expanding the toolkit for CNS-targeted delivery, supporting the rational design of next-generation therapeutics and research probes.
In summary, Angiopep-2 TFA offers a multifaceted platform for scientific advancement across several domains. Its exceptional BBB transport properties, receptor specificity, and compatibility with diverse molecular payloads underpin its utility in drug delivery, neuroscience research, gene therapy, nanotechnology, and peptide engineering. As research continues to explore the complexities of the CNS, this peptide stands at the forefront of innovation, enabling breakthroughs in targeted delivery and molecular imaging that were previously unattainable.
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