aStAx-35R is a stapled α-helical peptide containing a sequence designed for strong structural rigidity and enhanced binding affinity. The hydrocarbon staple enforces helical geometry and improves proteolytic stability. Researchers leverage its constrained architecture to study protein-protein interaction interfaces. Applications include stapled-peptide design, conformational control, and ligand optimization.
CAT No: R2608
CAS No:1418863-17-8
Synonyms/Alias:aStAx-35R;EX-A9239;HY-P10392;CS-1054504;1418863-17-8;
aStAx-35R is a specialized biochemical compound classified as a carotenoid derivative, designed for advanced research applications in the fields of oxidative stress, cellular signaling, and lipid metabolism. As a synthetic analogue of astaxanthin, it features a unique molecular structure that imparts potent antioxidant capabilities and distinctive physicochemical properties. Its robust free radical scavenging activity and ability to modulate redox-sensitive pathways make it a valuable reagent for exploring cellular defense mechanisms and the dynamics of lipid peroxidation. Researchers utilize this compound to investigate fundamental processes underlying cellular resilience, membrane stability, and metabolic homeostasis in a variety of experimental systems.
Oxidative Stress Research: aStAx-35R serves as a powerful tool for dissecting the biochemical pathways involved in oxidative damage and cellular protection. Its strong antioxidant activity enables researchers to model and quantify the effects of reactive oxygen species in vitro, facilitating studies on the mechanisms of lipid peroxidation, protein oxidation, and DNA damage. By incorporating this compound into experimental protocols, investigators can evaluate the efficacy of antioxidant interventions and gain mechanistic insight into cellular responses to oxidative insults.
Cellular Signaling Studies: The compound's influence on redox-sensitive signaling cascades provides an effective means to elucidate the role of carotenoids in cellular communication. aStAx-35R can be applied to cell culture systems to probe the modulation of transcription factors, kinases, and other signaling proteins responsive to changes in the intracellular redox environment. These studies are essential for understanding how oxidative and antioxidative forces shape gene expression, cellular adaptation, and stress responses.
Membrane Biophysics: Due to its lipophilic nature and structural similarity to naturally occurring carotenoids, aStAx-35R is ideally suited for research on membrane dynamics and stability. It can be incorporated into model membrane systems, liposomes, or lipid bilayers to assess its effects on membrane fluidity, permeability, and resistance to oxidative damage. Such investigations are crucial for unraveling the protective roles of carotenoids in biological membranes and for developing strategies to enhance membrane resilience in biotechnological applications.
Lipid Metabolism Analysis: The unique properties of aStAx-35R also make it a valuable probe in studies of lipid metabolism and storage. Its incorporation into cellular lipid pools can be monitored to investigate uptake, distribution, and metabolic transformation of carotenoid derivatives. Researchers leverage this compound to track lipid trafficking, assess the impact of antioxidants on lipid homeostasis, and explore the interplay between carotenoid metabolism and cellular energy balance.
Analytical Method Development: The defined chemical profile and spectroscopic features of aStAx-35R allow for its use as a reference standard or calibration compound in analytical chemistry. It supports the development and validation of chromatographic, spectrophotometric, and mass spectrometric methods for the detection and quantification of carotenoids and related antioxidants in complex biological matrices. This application is particularly relevant for laboratories establishing robust assays for antioxidant profiling, food chemistry, and biomarker discovery.
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