Contulakin G, a remarkable synthetic peptide in the realm of biomedicine, has gained prominence as an innovative experimental analgesic. Its inherent potency lies in its ability to meticulously target and restrain distinct receptors within the intricate nervous system.
CAT No: R2055
CAS No:229180-41-0
Chemical Name:(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[2-[[2-[[(2S)-4-carboxy-2-[[(2S)-4-carboxy-2-[[(2S)-3-hydroxy-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]butanoyl]amino]butanoyl]amino]acetyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]propanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
Contulakin G is a naturally occurring neuropeptide originally isolated from the venom of the marine cone snail, Conus geographus. Structurally, it is a glycosylated peptide featuring a unique O-linked disaccharide moiety, which distinguishes it from many other conotoxins and neuropeptides. Its primary biological activity centers on modulation of neuronal signaling, particularly through interaction with neuropeptide receptors of the neurotensin family. The distinctive structure and bioactivity of Contulakin G have made it a subject of significant interest in neuroscience, peptide chemistry, and receptor pharmacology research, where it serves as a valuable molecular tool for probing peptide-receptor interactions and neuronal function.
Neuroscience research: Contulakin G is widely employed in the study of neuronal signaling pathways, particularly those involving neurotensin receptors. By serving as a selective agonist, it enables researchers to dissect the physiological and pharmacological roles of neurotensin receptor subtypes in synaptic transmission, pain modulation, and neurochemical regulation. Its unique glycosylation pattern also provides insights into how post-translational modifications influence neuropeptide-receptor binding and downstream signaling events in neural tissues.
Peptide-receptor interaction studies: The peptide is a powerful probe for characterizing ligand-receptor specificity and affinity within the neurotensin receptor family. Its distinct structure, especially the glycosylated threonine residue, allows scientists to investigate the molecular determinants of receptor recognition and activation. Use of Contulakin G in binding assays and functional studies facilitates the mapping of critical contact points between peptides and G protein-coupled receptors, advancing the understanding of peptide ligand pharmacology.
Peptide synthesis and analog development: Synthetic analogs of Contulakin G are frequently generated to explore structure-activity relationships and to optimize peptide properties for research applications. By modifying specific amino acid residues or glycan structures, researchers can assess the impact of these alterations on biological activity, receptor selectivity, and stability. Such studies are instrumental in the rational design of novel neuropeptide mimetics and in expanding the toolbox for functional peptide research.
Glycopeptide research: The presence of an O-linked disaccharide on Contulakin G makes it a model compound for investigating the role of glycosylation in peptide function. Researchers utilize it to study how glycan modifications affect peptide folding, receptor interaction, and resistance to enzymatic degradation. These investigations contribute to the broader understanding of glycopeptide biology and inform strategies for designing glycosylated bioactive molecules with enhanced properties.
Pharmacological assay development: Contulakin G serves as a reference ligand in the development and validation of in vitro pharmacological assays targeting neuropeptide receptors. Its well-characterized activity profile enables the establishment of robust assay systems for screening receptor agonists or antagonists, evaluating signaling pathways, and quantifying receptor-ligand interactions. The peptide's use in these contexts supports drug discovery efforts and basic research focused on neuropeptide signaling mechanisms.
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