Galanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with Kis of both 1 nM.
CAT No: 10-101-317
CAS No:119418-04-1
Synonyms/Alias:119418-04-1;Galanin (1-30) (human);Galanin (1-30), human;CID 16133823;Galanin-1-30;DTXSID60583203;PUBCHEM_16133823;Galanin (human) trifluoroacetate salt;AKOS024456443;FG110297;Galanin human, >=97% (HPLC), powder;G12375;
Galanin, human is a neuropeptide composed of 30 amino acids, widely distributed throughout the central and peripheral nervous systems of mammals. It is encoded by the GAL gene and exerts its biological effects through interaction with specific G protein-coupled receptors, including GALR1, GALR2, and GALR3. As a highly conserved regulatory peptide, galanin is recognized for its significant modulatory roles in neurotransmission, hormone secretion, and neuroendocrine signaling. Its multifaceted activity and involvement in diverse physiological processes have made it a focal point in neurobiological research, particularly in studies of neuronal communication, synaptic plasticity, and neuropeptide signaling pathways.
Neuroscience research: Galanin is widely utilized in neuroscience to elucidate the mechanisms of neuropeptide-mediated modulation of synaptic activity. By applying synthetic human galanin in in vitro or in vivo models, researchers can investigate its influence on neuronal excitability, neurotransmitter release, and synaptic plasticity. These studies have been instrumental in advancing the understanding of how neuropeptides modulate neural circuit functions, especially in regions such as the hippocampus, hypothalamus, and spinal cord, where galaninergic signaling is prominent.
Receptor pharmacology: The peptide serves as a critical tool for characterizing the pharmacological properties of galanin receptors. By employing human galanin in receptor binding assays, signal transduction studies, or functional bioassays, investigators can delineate receptor subtype specificity, ligand affinity, and downstream signaling pathways. Such research is essential for mapping the physiological roles of GALR1, GALR2, and GALR3, as well as for screening novel receptor agonists, antagonists, or modulators in drug discovery and neuropharmacology.
Peptide-receptor interaction studies: Human galanin is frequently employed to probe the structural and functional determinants of peptide-receptor interactions. Through mutagenesis, structure-activity relationship (SAR) analyses, and biophysical characterization, scientists can dissect the binding interfaces and conformational dynamics that underlie galanin's selective activation of its receptors. These insights are crucial for rational design of peptide analogs with tailored bioactivity or improved receptor selectivity, enabling more precise manipulation of galaninergic signaling in experimental systems.
Endocrine regulation research: The peptide is instrumental in studies examining the modulation of hormone secretion and neuroendocrine integration. Galanin has been shown to influence the release of several pituitary and hypothalamic hormones, such as growth hormone, prolactin, and luteinizing hormone, through direct and indirect actions on neuroendocrine cells. Experimental application of human galanin in isolated tissue preparations or cell-based assays allows for detailed analysis of its regulatory effects on hormone dynamics, contributing to a deeper understanding of neuropeptide-hormone crosstalk.
Peptide signaling pathway analysis: Human galanin is an essential reagent for dissecting complex neuropeptide signaling pathways in various model systems. By modulating galaninergic tone in neuronal cultures, brain slices, or animal models, researchers can evaluate downstream effects on gene expression, second messenger systems, and cellular responses. Such experiments are fundamental for mapping the broader physiological consequences of galanin signaling, clarifying its roles in stress response, energy homeostasis, and neural adaptation.
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