Gly-Arg combines the flexibility of glycine with the strong basicity of arginine, enabling investigation of early folding and charge-driven interactions. The dipeptide serves as a useful probe in enzymatic recognition studies. Researchers evaluate its hydrogen-bond patterns and solution behavior. Applications span peptide synthesis development, binding analysis, and conformational modeling.
CAT No: R2630
CAS No:18635-55-7
Synonyms/Alias:Glycyl-L-arginine;H-Gly-Arg-OH;18635-55-7;L-Arginine, glycyl-;glycylarginine;Glycyl-Arginine;P56Q695EWK;Gly-Arg;Gly-L-Arg;NSC-334212;CHEBI:73860;UNII-P56Q695EWK;CHEMBL96806;(2S)-2-((2-Aminoacetyl)amino)-5-(diaminomethylideneamino)pentanoic acid;(2S)-2-[(2-aminoacetyl)amino]-5-(diaminomethylideneamino)pentanoic acid;(S)-2-(2-Aminoacetamido)-5-guanidinopentanoic acid;GR dipeptide;G-R Dipeptide;L-Glycyl-L-Arginine;Gly-L-Arg-OH;Glycine Arginine dipeptide;Glycine-Arginine dipeptide;2-((2-Amino-1-hydroxyethylidene)amino)-5-carbamimidamidopentanoate;2-[(2-Amino-1-hydroxyethylidene)amino]-5-carbamimidamidopentanoate;Glycinyl-L-arginine;Glycyl-L-arginine;;H-Gly-Arg;MFCD00190918;SCHEMBL187696;JLXVRFDTDUGQEE-YFKPBYRVSA-N;DTXSID801316438;HY-P4596;BDBM50407457;DA-53979;FG108046;CS-0655369;Q27144186;(2S)-2-(2-AMINOACETAMIDO)-5-CARBAMIMIDAMIDOPENTANOIC ACID;
Gly-Arg, also known as Glycyl-L-arginine, is a dipeptide composed of glycine and arginine linked by a peptide bond. This compound is widely recognized in biochemical and molecular biology research due to its unique combination of amino acid residues, which imparts distinctive physicochemical properties and functional potential. Gly-Arg exhibits high solubility in aqueous environments and demonstrates remarkable stability under typical laboratory conditions, making it a practical choice for a variety of experimental applications. Its constituent amino acids, glycine and arginine, are both fundamental to numerous cellular processes, and their dipeptide form offers advantages in terms of bioavailability and targeted reactivity compared to their free forms. Researchers leverage this peptide for its versatility in enzymatic studies, peptide synthesis, and as a model compound for investigating peptide transport and metabolism.
Peptide Transport Studies: Glycyl-L-arginine serves as a valuable model substrate in the exploration of peptide transport mechanisms across cellular membranes. By utilizing this dipeptide, scientists can investigate the specificity and kinetics of peptide transporters such as PEPT1 and PEPT2 in various cell types, including intestinal and renal epithelial cells. The use of Gly-Arg allows for the elucidation of transporter affinity, uptake rates, and potential competitive interactions with other di- and tripeptides. These studies contribute to a deeper understanding of nutrient absorption, drug delivery strategies, and the physiological roles of peptide transporters in health and disease.
Enzymatic Activity Assays: In enzymology research, Gly-Arg is frequently employed as a substrate to evaluate the activity and specificity of peptidases and proteases. Its well-defined structure enables precise monitoring of enzymatic cleavage, providing insights into substrate preferences and catalytic efficiencies of enzymes such as aminopeptidases, carboxypeptidases, and dipeptidyl peptidases. By analyzing the hydrolysis of this dipeptide, researchers can characterize enzyme kinetics, identify inhibitors, and screen for potential modulators, thereby advancing the development of novel biochemical assays and therapeutic agents targeting proteolytic pathways.
Peptide Synthesis and Modification: The dipeptide Gly-Arg is commonly used as a building block in solid-phase peptide synthesis and as a precursor for the generation of longer peptide chains. Its incorporation into synthetic peptides facilitates the study of structure-activity relationships, conformational dynamics, and interaction motifs in protein engineering and design. Additionally, Gly-Arg can be chemically modified to introduce functional groups or labels, enabling the creation of bioactive peptides, affinity tags, or molecular probes for advanced research applications in proteomics and cell biology.
Nutritional and Metabolic Research: Glycyl-L-arginine plays a significant role in studies focused on amino acid metabolism, nitrogen balance, and nutrient utilization. Researchers utilize this dipeptide to investigate absorption pathways, metabolic fate, and the bioavailability of arginine and glycine when delivered as a dipeptide versus their free forms. Such investigations help clarify the efficiency of peptide-based nutrient delivery systems and inform the design of specialized dietary supplements, enteral nutrition formulations, and metabolic studies in various biological models.
Cell Signaling and Functional Analysis: Gly-Arg is also explored for its potential effects on cellular signaling pathways, particularly those involving arginine-derived metabolites such as nitric oxide. By supplying arginine in a dipeptide form, scientists can assess its influence on signal transduction, gene expression, and cellular responses under different physiological and experimental conditions. This line of research enhances our understanding of how peptide-bound amino acids modulate cellular functions, providing valuable insights for the development of targeted research tools and experimental interventions. Through these diverse application directions, Gly-Arg continues to be an indispensable reagent in the toolkit of biochemical and molecular life sciences, supporting innovative research and discovery across multiple disciplines.
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