H-Glu-Gly-Arg-chloromethylketone trifluoroacetate salt is an irreversible active-site probe incorporating a chloromethylketone group for enzyme-interaction studies. Its sequence mimics native cleavage substrates while providing covalent reactivity. The peptide supports catalytic mechanism analysis. Applications include enzymology, protease profiling, and biochemical mapping.
1. The spatiotemporal control of signalling and trafficking of the GLP-1R
2. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
3. Implications of ligand-receptor binding kinetics on GLP-1R signalling
4. TMEM16F and dynamins control expansive plasma membrane reservoirs
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