(Hyp3,beta-(2-thienyl)-Ala5,Tyr(Me)8-(R)-Arg9)-Bradykinin

(Hyp3,beta-(2-thienyl)-Ala5,Tyr(Me)8,(R)-Arg9)-Bradykinin is a bradykinin analog with unique substitutions, including hydroxylated proline and thienylalanine. These modifications enhance its stability and receptor interaction, making it useful for studying bradykinin receptor-mediated effects in inflammation and vasodilation. This compound is utilized in cardiovascular research and inflammatory response modulation studies.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
(Hyp3,beta-(2-thienyl)-Ala5,Tyr(Me)8-(R)-Arg9)-Bradykinin(CAS 159768-75-9)

CAT No: B09040

CAS No:159768-75-9

Synonyms/Alias:Labradimil;Lobradimil;Cereport;159768-75-9;RMP-7;RMP 7;Labradimil [USAN:INN];DRG-0182;Labradimil [INN];(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S,4R)-1-[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-ylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-methoxyphenyl)propyl]amino]-5-(diaminomethylideneamino)pentanoic acid;UNII-2MK663C346;LABRADIMIL [USAN];2MK663C346;(S-(R*,R*))-L-Arginyl-L-prolyl-trans-4-hydroxy-L-prolyl-3-(2-thienyl)-L-alanylglycyl-L-seryl-N-(2-((4-((aminoiminomethyl)amino)-1-carboxybutyl)amino)-1-((4-methoxyphenyl)methyl)ethyl)-L-prolinamide;N2-((S)-2-(L-Arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-L-prolinamido)-3-(p-methoxyphenyl)propyl)-L-arginine;(S-(R*,R*))-L-Arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-N-(2-((4-(aminoiminomethyl)amino)-1-carboxybutyl)amino)-1-((4-methoxyphenyl)methyl)ethyl)-L-prolinamide;[Hyp3,Thi5,4-Me-Tyr8psi(CH2-NH)Arg9]bradykinin;Receptor mediated permeabilizer;RMP 7;Cereport;Bradykinin, 3-(trans-4-hydroxy-L-proline)-5-(3-(2-thienyl)-L-alanine)-8-de-L-phenylalanine-9-(N2-(2-amino-3-(4-methoxyphenyl)propyl)-L-arginine)-, (S)-;L-Arginine, L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolyl-3-(2-thienyl)-L-alanylglycyl-L-seryl-L-prolyl-O-methyl-L-tyrosyl-psi(CH2-NH)-;L-Prolinamide, L-arginyl-L-prolyl-trans-4-hydroxy-L-prolyl-3-(2-thienyl)-L-alanylglycyl-L-seryl-N-(2-((4-((aminoiminomethyl)amino)-1-carboxybutyl)amino)-1-((4-methoxyphenyl)methyl)ethyl)-, (S-(R*,R*))-;N(SUP 2)2-((S)-2-(L-ARGINYL-L-PROLYL-TRANS-4-HYDROXY-L-PROLYGLYCYL-3-(2-THIENYL)-L-ALANYL-L-SERYL-L-PROLINAMIDO)-3-(P-METHOXYPHENYL)PROPYL)-L-ARGININE;(Hyp3,Thi5,4-Me-Tyr8psi(CH2-NH)Arg9)bradykinin;labradimilum;(2S)-2-(((2S)-2-(((2S)-1-((2S)-2-(((2S)-2-((2-(((2S,4R)-1-((2S)-1-((2S)-2-amino-5-(diaminomethylideneamino)pentanoyl)pyrrolidine-2-carbonyl)-4-hydroxypyrrolidine-2-carbonyl)amino)acetyl)amino)-3-thiophen-2-ylpropanoyl)amino)-3-hydroxypropanoyl)pyrrolidine-2-carbonyl)amino)-3-(4-methoxyphenyl)propyl)amino)-5-(diaminomethylideneamino)pentanoic acid;GTPL672;SCHEMBL411837;CHEMBL2105864;NSC950021;AKOS040748717;DB06549;DA-48755;FH109887;HY-105155;CS-0025139;Q27078449;(Hyp 3,b-(2-thienyl)-Ala5,Tyr(Me)8-psi(CH2NH)Arg9)-Bradykinin trifluoroacetate salt;(Hyp3,beta-(2-thienyl)-Ala5,Tyr(Me)8-psi(CH2NH)Arg9)-Bradykinin trifluoroacetate salt;L-Prolinamide, L-Arginyl-L-prolyl-trans-4-hydroxy-L-prolyl-3-(2-thienyl)-L-alanylglycl-L-seryl-N-(2-((4-((aminoiminomethyl)amino)-1--carboxybutyl)amino)-1-((4-methoxyphenyl)methyl)ethyl)-, (S-(R*,R*));Labradimil, Lobradimil, RMP-7;H-Arg-Pro-Hyp-Gly-?-(2-thienyl)-Ala-Ser-Pro-Tyr(Me)-psi(CH2NH)Arg-OH trifluoroacetate salt;N(sup 2)-((S)-2-(L-Arginyl-L-prolyl-trans-4-hydroxy-L-prolyglycyl-3-(2-thienyl)-L-alanyl-L-seryl-L-prolinamido)-3-(p-methoxyphenyl)propyl)-L-arginine;

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M.F/Formula
C49H75N15O12S
M.W/Mr.
1098.3
Sequence
three Letter Code: H-Arg-Pro-Hyp-Gly-β-(2-thienyl)-Ala-Ser-Pro-Tyr(Me)-psi(CH₂NH)Arg-OH trifluoroacetate salt
Source#
Synthetic
InChI
InChI=1S/C49H75N15O12S/c1-76-31-14-12-28(13-15-31)21-29(24-57-34(47(74)75)9-3-17-56-49(53)54)59-43(70)37-10-4-18-62(37)45(72)36(27-65)61-41(68)35(23-32-7-6-20-77-32)60-40(67)25-58-42(69)39-22-30(66)26-64(39)46(73)38-11-5-19-63(38)44(71)33(50)8-2-16-55-48(51)52/h6-7,12-15,20,29-30,33-39,57,65-66H,2-5,8-11,16-19,21-27,50H2,1H3,(H,58,69)(H,59,70)(H,60,67)(H,61,68)(H,74,75)(H4,51,52,55)(H4,53,54,56)/t29-,30+,33-,34-,35-,36-,37-,38-,39-/m0/s1
InChI Key
IDXCXSCCZNCXCL-XMADEQCMSA-N

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