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ICI 154,129

ICI 154129, a peptide analog, is a selective δ opioid antagonist.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: R1073

CAS No:83420-94-4

Synonyms/Alias:83420-94-4;ICI 154129;ICI 154,129;ICI-154129;UNII-97BUE7NR2M;(2S)-2-[[(2S)-2-[2-[[2-[[(2S)-2-[bis(prop-2-enyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]ethylsulfanyl]-3-phenylpropanoyl]amino]-4-methylpentanoic acid;N,N-Bis(allyl)-tyr-gly-gly-psi-methylthio-phe-leu;M 154,129;M-154,129;97BUE7NR2M;N,N-Bis(allyl)-tyrosyl-glycyl-glycyl-psi-methylthio-phenylalanyl-leucine;DTXSID00232349;N,N-Di-2-propenyl-L-tyrosylglycyl-(alphaS)-alpha-((2-aminoethyl)thio)benzenepropanoyl-L-leucine;Glycinamide, N,N-di-2-propenyl-L-tyrosyl-N-(2-((2-((1-carboxy-3-methylbutyl)amino)-2-oxo-1-(phenylmethyl)ethyl)thio)ethyl)-, (S-(R*,R*))-;L-Leucine, N,N-di-2-propenyl-L-tyrosylglycyl-(alphaS)-alpha-((2-aminoethyl)thio)benzenepropanoyl-;M-154129;L-LEUCINE, N,N-DI-2-PROPEN-1-YL-L-TYROSYLGLYCYL-(.ALPHA.S)-.ALPHA.-((2-AMINOETHYL)THIO)BENZENEPROPANOYL-;SCHEMBL4405821;ICI154129;ICI 154129;M 154129;M154129;M-154129;DTXCID50154840;AKOS024458661;HY-101233;CS-0021020;Q27272001;((S)-2-((2-(2-((S)-2-(Diallylamino)-3-(4-hydroxyphenyl)propanamido)acetamido)ethyl)thio)-3-phenylpropanoyl)-L-leucine;L-LEUCINE, N,N-DI-2-PROPEN-1-YL-L-TYROSYLGLYCYL-(ALPHAS)-ALPHA-((2-AMINOETHYL)THIO)BENZENEPROPANOYL-;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C34H46N4O6S
M.W/Mr.
638.8
Sequence
YGFL(Modifications: Tyr-1 = N,N-diallyl-Tyr, Gly-2 - Phe-3 peptide bond replaced with Psi-(CH2S))
Labeling Target
Opioid Receptor
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Activity
Antagonist
Long-term Storage Conditions
Soluble in DMSO
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Short-term Storage Conditions
Dry, dark and at 0 - 4 °C
Solubility
-20 °C
InChI
InChI=1S/C34H46N4O6S/c1-5-17-38(18-6-2)29(21-26-12-14-27(39)15-13-26)32(41)36-23-31(40)35-16-19-45-30(22-25-10-8-7-9-11-25)33(42)37-28(34(43)44)20-24(3)4/h5-15,24,28-30,39H,1-2,16-23H2,3-4H3,(H,35,40)(H,36,41)(H,37,42)(H,43,44)/t28-,29-,30-/m0/s1
InChI Key
CZRZYRKTYLLLRL-DTXPUJKBSA-N
Isomeric SMILES
CC(C)C[C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)SCCNC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)N(CC=C)CC=C
BoilingPoint
929.4ºC at 760 mmHg
ShelfLife
>3 years if stored properly
Melting Point
N/A

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