J-2156 is a peptide derivative used to investigate receptor-linked pathways and structural motifs influencing ligand activity. The sequence promotes studies of aromatic interactions, backbone orientation, and binding thermodynamics. Researchers apply it in mechanistic and conformational analyses. Its stability supports broad biochemical experimentation.
CAT No: PI-009
CAS No:848647-56-3
Synonyms/Alias:J-2156;848647-56-3;UNII-H35JAI9M2X;(2S)-4-amino-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-2-[(4-methylnaphthalen-1-yl)sulfonylamino]butanamide;J 2156;J-2156 TFA salt;H35JAI9M2X;(1'S, 2S)-4-amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide;J2156;(1'S,2S)-4-AMINO-N-(1'-CARBAMOYL-2'-PHENYLETHYL)-2-(4''-METHYL-1''-NAPHTHALENESULFONYLAMINO)BUTANAMIDE;(2~{S})-2-[[(2~{S})-4-azanyl-2-[(4-methylnaphthalen-1-yl)sulfonylamino]butanoyl]amino]-3-phenyl-propanimidic acid;BENZENEPROPANAMIDE, .ALPHA.-(((2S)-4-AMINO-2-(((4-METHYL-1-NAPHTHALENYL)SULFONYL)AMINO)-1-OXOBUTYL)AMINO)-, (.ALPHA.S)-;(2S)-4-amino-N-((2S)-1-amino-1-oxo-3-phenylpropan-2-yl)-2-((4-methylnaphthalen-1-yl)sulfonylamino)butanamide;SCHEMBL4640775;CHEMBL4451852;GTPL10115;GLXC-26290;AKOS040733479;DA-64601;DA-74619;HY-111615;CS-0088634;EN300-1719195;Q27279583;(2S)-4-amino-N-[(1S)-1-carbamoyl-2-phenylethyl]-2-(4-methylnaphthalene-1-sulfonamido)butanamide;(S)-4-Amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-2-((4-methylnaphthalene)-1-sulfonamido)butanamide;BENZENEPROPANAMIDE, ALPHA-(((2S)-4-AMINO-2-(((4-METHYL-1-NAPHTHALENYL)SULFONYL)AMINO)-1-OXOBUTYL)AMINO)-, (ALPHAS)-;I8B;
Chemical Name:(2S)-4-amino-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-2-[(4-methylnaphthalen-1-yl)sulfonylamino]butanamide
J-2156 is a synthetic peptide compound recognized for its role as a selective agonist of the somatostatin receptor subtype 4 (SSTR4). As a member of the somatostatin analog family, it exhibits high affinity and specificity for SSTR4, making it an important tool in the study of somatostatin-mediated signaling pathways. Its unique structural features enable researchers to dissect receptor subtype-specific responses, which are critical for understanding the diverse physiological roles of somatostatin receptors in neuroendocrine regulation, inflammation, and cellular communication. The compound's biochemical profile has established it as a valuable reagent in both basic and applied research settings focused on peptide-receptor interactions.
Receptor Pharmacology: J-2156 is widely used in receptor pharmacology studies to characterize the functional properties of the SSTR4 subtype. By selectively activating SSTR4, it allows researchers to delineate the downstream signaling events and physiological effects mediated by this receptor, distinguishing them from those associated with other somatostatin receptor subtypes. This specificity is essential for mapping receptor-ligand interactions, evaluating receptor distribution in various tissues, and investigating the pharmacodynamics of novel peptide analogs.
Signal Transduction Research: The compound serves as a robust tool for investigating intracellular signaling cascades initiated by SSTR4 engagement. Experimental use of this peptide agonist enables detailed analysis of G protein-coupled receptor (GPCR) pathways, including the modulation of cyclic AMP levels, calcium flux, and kinase activation. Such studies provide fundamental insights into how SSTR4 activation influences cellular responses, gene expression, and functional outcomes in target cell populations.
Neuroendocrine Function Studies: J-2156 is instrumental in elucidating the specific contributions of SSTR4 to neuroendocrine regulation. By selectively targeting this receptor, researchers can examine its involvement in hormone secretion, neurotransmitter release, and feedback mechanisms within the central and peripheral nervous systems. These investigations help clarify the physiological roles of SSTR4 in processes such as stress response, appetite regulation, and neuroprotection, contributing to a broader understanding of peptide hormone networks.
Peptide Drug Discovery: The selective agonistic properties of J-2156 make it a valuable reference compound in the development of new peptide-based therapeutics targeting somatostatin receptors. Its well-characterized pharmacological profile provides a benchmark for screening and optimizing novel analogs with improved selectivity or potency. Researchers utilize this peptide to validate assay systems, assess structure-activity relationships, and support preclinical evaluation of candidate molecules in drug discovery pipelines.
Analytical Method Development: In addition to its functional applications, J-2156 is employed as a standard or positive control in analytical assays designed to measure SSTR4 activity or expression. Its predictable binding characteristics and functional readouts facilitate the development and validation of bioassays, receptor binding studies, and high-throughput screening platforms. These applications are essential for ensuring assay reliability, reproducibility, and sensitivity in both academic and industrial research environments.
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