L-HISTIDINE (<5% D) (RING-EPSILON-15N+) contains the amino acid skeleton with an imidazole side chain characteristic of histidine, featuring an epsilon-nitrogen labeled with 15N and present as a ring-15N+ isotopically enriched form. The molecule bears a free α-amino group and a free α-carboxyl group, while the imidazole ring provides a basic, protonatable functionality that can participate in acid-base equilibria and metal coordination in solution; the product name indicates an L-enantiomeric form with less than 5% D. This isotopically labeled amino acid is used for NMR, MS, and tracer-based analytical studies of histidine-containing peptides and proteins, including incorporation into peptide synthesis workflows and subsequent structural or binding investigations where the labeled imidazole nitrogen improves signal specificity.
CAT No: L-Iso-0302
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