Nemifitide diTFA is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF), can cross the blood-brain barrier.
CAT No: R1866
CAS No:204992-09-6
Synonyms/Alias:Nemifitide ditriflutate;204992-09-6;INN-00835;Nemifitide (diTFA);Nemifitide ditriflutate [USAN];INN 00835;NETAMIFTIDE;Nemifitide bis(trifluoroacetate);UNII-27454M5E8Z;27454M5E8Z;Nemifitide ditriflutate (USAN);(2S,4R)-1-[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]-N-[(2S)-1-[[2-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-hydroxypyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid;INN00835;NEMIFITIDE BIS(TRIFLUOROACETATE) [MI];4-fluoro-L-phenylalanyl-trans-4-hydroxy-L-prolyl-L-arginyl-glycyl-tryptophanamide ditrifluoroacetate;4-Fluoro-L-phenylalanyl-trans-4-hydroxy-L-prolyl-L-arginylglycyl-L-tryptophanamide bis(trifluoroacetate) (salt);L-Tryptophanamide, 4-fluoro-L-phenylalanyl-(4R)-4-hydroxy-L-prolyl-L-arginylglycyl-bis(trifluoroacetate) (salt);Nemifitide diTFA?;Netamiftide trifluoroacetate;CHEMBL2146091;QXCFOJXOLMOPRK-QOXNQHIRSA-N;HY-105077A;MS-31724;CS-0025815;D05139;Q27254165;L-tryptophanamide, 4-fluoro-L-phenylalanyl-(4R)-4-hydroxy-L-prolyl-L-arginylglycyl-bis(trifluoroacetate) (salt);
Chemical Name:(2S,4R)-1-[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]-N-[(2S)-1-[[2-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-hydroxypyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Nemifitide (diTFA) is a synthetic peptide compound characterized by its unique amino acid sequence and modified with di-trifluoroacetate (diTFA) as a counterion. As a member of the peptide family, Nemifitide has attracted considerable interest within the biochemical and pharmaceutical research communities due to its structural and functional properties. Its synthetic nature allows for precise investigation of peptide-based mechanisms and interactions, making it a valuable tool for studies focused on peptide signaling, receptor binding, and molecular pathway elucidation. The compound's stability and defined composition further enhance its suitability for advanced experimental designs, particularly in contexts requiring high specificity and reproducibility.
Peptide mechanism research: Nemifitide is frequently utilized in studies aimed at elucidating the mechanisms of peptide signaling and receptor-ligand interactions. Researchers leverage its well-defined sequence to probe the molecular determinants of peptide affinity, selectivity, and downstream signaling cascades. By employing Nemifitide in binding assays, structure-activity relationship studies, and receptor mapping experiments, investigators can dissect the contributions of specific amino acid residues to biological function, thereby advancing the understanding of peptide-mediated communication at the cellular and molecular levels.
Peptide synthesis validation: In the context of synthetic peptide production and quality control, Nemifitide serves as a benchmark for evaluating peptide synthesis protocols and purification strategies. Its consistent chemical structure and known properties make it an ideal reference standard for optimizing solid-phase peptide synthesis, chromatographic purification, and analytical characterization methods. By incorporating Nemifitide into validation workflows, laboratories can ensure the reliability and reproducibility of their peptide manufacturing processes, ultimately supporting the development of high-quality research reagents.
Functional peptide assays: The compound is also employed in a variety of functional assays designed to assess peptide activity under controlled experimental conditions. Its application extends to in vitro studies that investigate peptide-induced cellular responses, such as signal transduction, second messenger generation, or gene expression modulation. Utilizing Nemifitide in these assays enables researchers to establish dose-response relationships, evaluate peptide stability, and characterize the functional consequences of sequence modifications, thereby facilitating the rational design of novel bioactive peptides.
Analytical method development: Nemifitide is valuable in the development and optimization of analytical techniques for peptide quantification and identification. Its defined molecular features make it a preferred standard for mass spectrometry calibration, high-performance liquid chromatography (HPLC) method validation, and peptide mapping protocols. By integrating this peptide into analytical workflows, scientists can enhance the accuracy, sensitivity, and reproducibility of their peptide detection and quantification strategies, supporting robust data generation in both basic and applied research settings.
Peptide-protein interaction studies: The compound's unique sequence and structural attributes allow it to function as a model system in studies of peptide-protein interactions. Researchers use Nemifitide to investigate the binding kinetics, thermodynamics, and specificity of peptide engagement with target proteins, such as receptors, enzymes, or transporters. These experiments provide critical insights into the molecular basis of peptide recognition and complex formation, informing the design of peptide-based probes, inhibitors, or modulators for diverse biochemical applications.
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