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Nemifitide (diTFA)

Nemifitide diTFA is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF), can cross the blood-brain barrier.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Nemifitide (diTFA)(CAS 204992-09-6)

CAT No: R1866

CAS No:204992-09-6

Synonyms/Alias:Nemifitide ditriflutate;204992-09-6;INN-00835;Nemifitide (diTFA);Nemifitide ditriflutate [USAN];INN 00835;NETAMIFTIDE;Nemifitide bis(trifluoroacetate);UNII-27454M5E8Z;27454M5E8Z;Nemifitide ditriflutate (USAN);(2S,4R)-1-[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]-N-[(2S)-1-[[2-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-hydroxypyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid;INN00835;NEMIFITIDE BIS(TRIFLUOROACETATE) [MI];4-fluoro-L-phenylalanyl-trans-4-hydroxy-L-prolyl-L-arginyl-glycyl-tryptophanamide ditrifluoroacetate;4-Fluoro-L-phenylalanyl-trans-4-hydroxy-L-prolyl-L-arginylglycyl-L-tryptophanamide bis(trifluoroacetate) (salt);L-Tryptophanamide, 4-fluoro-L-phenylalanyl-(4R)-4-hydroxy-L-prolyl-L-arginylglycyl-bis(trifluoroacetate) (salt);Nemifitide diTFA?;Netamiftide trifluoroacetate;CHEMBL2146091;QXCFOJXOLMOPRK-QOXNQHIRSA-N;HY-105077A;MS-31724;CS-0025815;D05139;Q27254165;L-tryptophanamide, 4-fluoro-L-phenylalanyl-(4R)-4-hydroxy-L-prolyl-L-arginylglycyl-bis(trifluoroacetate) (salt);

Chemical Name:(2S,4R)-1-[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]-N-[(2S)-1-[[2-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-hydroxypyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C37H45F7N10O10
M.W/Mr.
922.8
Sequence
One Letter Code:XXRGW
Three Letter Code:H-Phe(4-F)-Hyp-Arg-Gly-Trp-NH2.2TFA
Shipping Condition
Wet ice in continental US; may vary elsewhere
InChI
InChI=1S/C33H43FN10O6.2C2HF3O2/c34-20-9-7-18(8-10-20)12-23(35)32(50)44-17-21(45)14-27(44)31(49)43-25(6-3-11-39-33(37)38)30(48)41-16-28(46)42-26(29(36)47)13-19-15-40-24-5-2-1-4-22(19)24;2*3-2(4,5)1(6)7/h1-2,4-5,7-10,15,21,23,25-27,40,45H,3,6,11-14,16-17,35H2,(H2,36,47)(H,41,48)(H,42,46)(H,43,49)(H4,37,38,39);2*(H,6,7)/t21-,23+,25+,26+,27+;;/m1../s1
InChI Key
QXCFOJXOLMOPRK-QOXNQHIRSA-N
Canonical SMILES
C1C(CN(C1C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)C(=O)C(CC4=CC=C(C=C4)F)N)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O
Isomeric SMILES
C1[C@H](CN([C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N)C(=O)[C@H](CC4=CC=C(C=C4)F)N)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O

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