Neuronostatin-13 human is a 13-amino acid peptide hormone encoded by the somatostatin gene and plays an important role in the regulation of hormonal and cardiac function.
CAT No: R1539
CAS No:1096485-24-3
Synonyms/Alias:1096485-24-3;Neuronostatin-13 (human, canine, porcine) trifluoroacetate salt;Neuronostatin-13 (human);DA-56124;FN109920;G13777;H-Leu-Arg-Gln-Phe-Leu-Gln-Lys-Ser-Leu-Ala-Ala-Ala-Ala-NH2; H-LRQFLQKSLAAAA-NH2;
Neuronostatin-13 human is a synthetic peptide fragment derived from the human neuronostatin precursor, itself a product of the somatostatin gene. As a biologically active neuropeptide, it is distinguished by its unique sequence and functional properties within the central nervous system and peripheral tissues. Researchers have identified neuronostatin peptides as modulators of neuroendocrine signaling, with emerging roles in the regulation of appetite, energy homeostasis, and neuronal excitability. The availability of the 13-amino acid human variant enables precise exploration of its physiological functions and molecular mechanisms, making it a valuable tool for peptide research and neurobiological investigations.
Neuroendocrine signaling studies: Neuronostatin-13 is frequently employed in research aimed at elucidating the complex regulatory networks of neuroendocrine communication. Its sequence-specific activity allows investigators to probe the signaling pathways that govern hormone secretion and neuronal responses. By applying this peptide to in vitro or ex vivo systems, researchers can dissect its influence on hypothalamic circuits, pituitary cell activity, and downstream hormone release, thereby advancing understanding of neuropeptide-mediated regulation in both neural and endocrine contexts.
Peptide-receptor interaction analysis: The 13-residue fragment serves as a model ligand for studying peptide-receptor dynamics in neuronal and endocrine tissues. Utilizing receptor-binding assays and functional readouts, scientists can characterize the affinity, selectivity, and downstream signaling effects of neuronostatin-13 on candidate G protein-coupled receptors or other membrane-bound targets. Such studies are essential for mapping the molecular determinants of neuropeptide recognition and for identifying potential receptor subtypes involved in neuronostatin-mediated processes.
Appetite and energy homeostasis research: Given its structural relation to the somatostatin family and emerging evidence of its role in feeding behavior, neuronostatin-13 is a key reagent for investigating the molecular basis of appetite regulation and metabolic control. Experimental models employing this peptide allow for the assessment of its effects on food intake, energy expenditure, and related metabolic parameters. These studies contribute to a deeper understanding of the neurochemical pathways that integrate nutritional status with central and peripheral metabolic responses.
Electrophysiological investigations: The peptide is utilized in electrophysiological experiments to examine its direct effects on neuronal excitability, synaptic transmission, and membrane potential modulation. By incorporating neuronostatin-13 into patch-clamp or field potential recording protocols, researchers can quantify its impact on neuronal firing patterns and synaptic plasticity. Such analyses are instrumental in delineating the functional roles of neuropeptides in modulating neural circuit activity and information processing.
Peptide structure-activity relationship (SAR) studies: Neuronostatin-13 provides a defined template for systematic structure-activity relationship investigations within the neuropeptide field. By modifying specific residues or creating analogs based on its sequence, scientists can evaluate how structural changes influence biological activity, receptor affinity, and signaling efficacy. These SAR studies not only deepen insight into the molecular determinants of function for neuronostatin peptides but also inform the rational design of novel peptide tools or probes for neurobiological research.
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