Nifalatide is a gastrointestinal compound.
CAT No: 10-101-92
CAS No:73385-60-1
Synonyms/Alias:L-Tyrosyl-S-oxido-D-methionylglycyl-4-nitro-L-phenylalanyl-L-prolinamide
Nifalatide is a synthetic peptide compound designed to mimic or modulate specific biological functions through its sequence-derived interactions with target proteins or receptors. As a member of the peptide research class, it offers a versatile platform for probing cellular mechanisms and signaling pathways. The structure of Nifalatide enables it to participate in molecular processes relevant to neurobiology, receptor binding studies, and signal transduction research. Its defined peptide backbone and functional groups make it valuable for in vitro experimentation, providing researchers with a precise tool to dissect complex biochemical interactions and advance the understanding of peptide-mediated physiological phenomena.
Neurobiology research: Nifalatide serves as a specialized probe in neurobiological studies, particularly for investigating peptide-mediated signaling within neuronal systems. Its sequence is designed to interact with neural receptors or modulate synaptic transmission, making it useful for elucidating the molecular underpinnings of neurotransmitter release, receptor activation, or downstream signaling cascades. By incorporating this peptide into cell-based assays or electrophysiological experiments, scientists can gain insights into the roles of endogenous peptides in neuronal communication and plasticity.
Receptor binding assays: The compound is well suited for use in receptor binding and ligand interaction studies. Its defined structure allows for the characterization of binding affinity and specificity toward target receptors, enabling the mapping of peptide-receptor interfaces and the identification of critical contact residues. Such studies are essential for understanding the molecular basis of receptor activation, desensitization, or antagonism, and for screening potential modulators in drug discovery pipelines.
Signal transduction analysis: Nifalatide is frequently employed in the analysis of intracellular signaling pathways, where it can function as an agonist, antagonist, or modulator depending on the experimental context. By stimulating or inhibiting specific signaling cascades, the peptide aids researchers in delineating pathway architecture, quantifying downstream effector responses, and identifying regulatory checkpoints. These applications are fundamental for unraveling the complexities of cellular communication networks and for validating novel targets in biochemical research.
Peptide structure-function studies: The compound provides a valuable model for investigating the relationship between peptide sequence, conformation, and biological activity. By systematically modifying its amino acid composition or structural motifs, researchers can assess how changes impact binding, stability, or functional efficacy. Such studies contribute to a deeper understanding of peptide design principles, inform the development of next-generation analogs, and support the engineering of peptides with tailored properties for research applications.
Analytical method development: Nifalatide is also utilized as a reference standard or calibration material in the development and validation of analytical techniques such as high-performance liquid chromatography (HPLC), mass spectrometry, and capillary electrophoresis. Its well-characterized properties support the optimization of detection protocols, quantification of peptide concentrations, and assessment of method sensitivity or reproducibility. These applications are critical for ensuring the accuracy and reliability of peptide analysis in research and quality control laboratories.
This study was a parallel, double-blind, placebo-controlled evaluation of acute doses of nifalatide, an enkephalin analog, in subjects with castor oil-induced diarrhea. Seventy-two subjects completed the study. The time to first stool after castor oil administration was significantly greater after the 16 and 48 mg doses of nifalatide as compared with placebo dosing. The same doses of nifalatide also decreased the overall stool frequency, the frequency of abdominal cramping, and the incidence of nausea and vomiting. There were no clinically significant, drug-related changes in the physical examination results, ECG, vital signs, or clinical laboratory parameters. The only increased adverse experiences that appeared to be related to the drug were dizziness and mild dry mouth.
Ryan, J., Leighton, J., Kirksey, D., & McMahon, G. (1986). Evaluation of an enkephalin analog in men with castor oil–induced diarrhea. Clinical Pharmacology & Therapeutics, 39(1), 40-42.
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