Nifalatide is a gastrointestinal compound.
CAT No: 10-101-92
CAS No:73385-60-1
Synonyms/Alias:L-Tyrosyl-S-oxido-D-methionylglycyl-4-nitro-L-phenylalanyl-L-prolinamide
Nifalatide is a synthetic carbohydrate-based compound designed to facilitate advanced research in glycobiology, cell signaling, and molecular recognition. Characterized by its unique glycan structure, Nifalatide offers researchers a versatile tool for probing carbohydrate-mediated interactions and elucidating the roles of glycoconjugates in diverse biological systems. Its stability, solubility, and compatibility with a wide range of experimental conditions make it an attractive choice for laboratories seeking to explore the functional significance of carbohydrate motifs in both in vitro and in vivo settings. The molecular architecture of Nifalatide enables precise engagement with lectins, glycan-binding proteins, and various cell surface receptors, supporting a multitude of investigative pathways in fundamental and applied sciences.
Glycobiology Research: Nifalatide serves as a valuable molecular probe in the study of glycan recognition and function. Its well-defined structure allows scientists to investigate how specific carbohydrate sequences modulate protein-glycan interactions, which are central to processes such as cell adhesion, immune response, and pathogen recognition. By incorporating Nifalatide into binding assays, surface plasmon resonance studies, or glycan microarrays, researchers can dissect the binding specificities of lectins and other glycan-interacting proteins, advancing our understanding of the glycome's complexity. Cell Signaling Pathway Analysis: In cellular signaling studies, Nifalatide is utilized to mimic or inhibit endogenous glycan structures, thereby influencing receptor activation and downstream signaling cascades. By modulating glycan-mediated communication at the cell surface, it becomes possible to delineate the roles of carbohydrate ligands in processes such as cell migration, proliferation, and differentiation. This application is especially relevant in the context of developmental biology and cancer research, where aberrant glycosylation patterns often drive disease progression.
Targeted Drug Delivery Systems: The unique binding properties of Nifalatide are harnessed in the development of targeted drug delivery strategies. By conjugating therapeutic agents or imaging probes to the carbohydrate scaffold, researchers can exploit glycan-receptor interactions to achieve selective delivery to specific cell types or tissues. This approach enhances the precision of experimental therapeutics, minimizes off-target effects, and enables the study of targeted uptake mechanisms in a controlled environment. The versatility of Nifalatide's structure supports its integration into nanoparticles, liposomes, or other carrier systems designed for targeted applications.
Biomarker Discovery and Validation: Nifalatide is increasingly employed in biomarker research, where its interaction profile with glycan-binding proteins aids in identifying disease-specific glycosylation patterns. By serving as a reference standard or affinity reagent in glycomics workflows, it contributes to the detection and characterization of novel carbohydrate biomarkers associated with pathological states. The use of Nifalatide in mass spectrometry-based assays, immunoaffinity purification, or biosensor platforms accelerates the validation of glycan-based diagnostic targets, supporting translational research initiatives.
Synthetic Glycoconjugate Engineering: The robust chemical properties of Nifalatide make it an excellent building block for the synthesis of custom glycoconjugates. Researchers leverage its modularity to construct complex glycopeptides, glycolipids, or neoglycoproteins for use in structure-activity relationship studies or vaccine design. Through site-specific conjugation strategies, it is possible to generate multivalent glycan displays that mimic natural cell-surface architectures, enabling detailed investigations into multivalent binding phenomena and immune recognition.
Biophysical Characterization: Nifalatide finds application in a variety of biophysical assays aimed at elucidating carbohydrate-protein interactions at the molecular level. Techniques such as isothermal titration calorimetry, nuclear magnetic resonance spectroscopy, and X-ray crystallography benefit from its defined structure, allowing for quantitative and structural analyses of binding events. These studies provide critical insights into the thermodynamics and structural determinants of glycan recognition, informing the rational design of glycomimetic ligands and therapeutic candidates. With its broad utility across multiple research domains, Nifalatide continues to empower scientists in unraveling the complexities of carbohydrate-mediated biology.
This study was a parallel, double-blind, placebo-controlled evaluation of acute doses of nifalatide, an enkephalin analog, in subjects with castor oil-induced diarrhea. Seventy-two subjects completed the study. The time to first stool after castor oil administration was significantly greater after the 16 and 48 mg doses of nifalatide as compared with placebo dosing. The same doses of nifalatide also decreased the overall stool frequency, the frequency of abdominal cramping, and the incidence of nausea and vomiting. There were no clinically significant, drug-related changes in the physical examination results, ECG, vital signs, or clinical laboratory parameters. The only increased adverse experiences that appeared to be related to the drug were dizziness and mild dry mouth.
Ryan, J., Leighton, J., Kirksey, D., & McMahon, G. (1986). Evaluation of an enkephalin analog in men with castor oil–induced diarrhea. Clinical Pharmacology & Therapeutics, 39(1), 40-42.
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