(Nle13,Glu14)-Motilin (human, porcine) is a motilin analog bearing norleucine and glutamate substitutions that influence helical stability and charge distribution. These changes fine-tune receptor interaction and peptide conformation. The analog supports biochemical studies of gastrointestinal peptide signaling and motilin receptor mapping. Researchers use it to explore sequence determinants of motilin family ligands.
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