Nociceptin, a heptadecapeptide, is the endogenous ligand of the nociceptin receptor, acting as a potent anti-analgesic.
CAT No: R1564
CAS No:170713-75-4
Synonyms/Alias:Nociceptin;Orphanin FQ;170713-75-4;Orphanin FQ (swine);Orphanin FQ (rat);Orphanin FQ (human);Nociceptin/orphanin FQ;Human nociceptin;Nociceptin (1-17);N-OFQ peptide;Nociceptin (human);Orphanin FQ (pig);nociceptin-orphanin FQ;FGGFTGARKSARKLANQ;7AYI9N34FF;CHEBI:80266;NOCICEPTIN [MI];DTXSID60168933;L-Glutamine, L-phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-alanyl-L-asparaginyl-;PheGlyGlyPheThrGlyAlaArgLysSerAlaArgLysLeuAlaAsnGln;Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln;PHE-GLY-GLY-PHE-THR-GLY-ALA-ARG-LYS-SER-UNK-ALA-ARG-LYS-LEU-ALA-ASN-GLN;L-Phe-Gly-Gly-L-Phe-L-Thr-Gly-L-Ala-L-Arg-L-Lys-L-Ser-L-Ala-L-Arg-L-Lys-L-Leu-L-Ala-L-Asn-L-Gln;L-phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-alanyl-L-asparaginyl-L-glutamine;UNII-7AYI9N34FF;orphanin-fq;Nociceptin(Orphanin FQ);CHEMBL396460;GTPL1681;DTXCID1091424;BDBM50004178;HB2424;AKOS024458690;C79H129N27O22;NCGC00167266-01;DA-76240;FN108853;TS-10285;Q4327722;BRD-K05717154-001-01-1;
Nociceptin, also known as orphanin FQ, is a neuropeptide belonging to the opioid peptide family, characterized by its unique affinity for the nociceptin/orphanin FQ peptide (NOP) receptor. Structurally related to classical opioids but functionally distinct, it plays a pivotal role in modulating pain signaling, stress responses, and a variety of neurophysiological processes. The peptide's significance in neurobiology and pharmacology has made it a valuable research tool for elucidating non-classical opioid pathways, offering insights into complex neural mechanisms that diverge from those mediated by traditional opioid receptors.
Receptor pharmacology: Nociceptin is extensively employed in receptor binding studies to investigate the pharmacodynamics of the NOP receptor. By acting as a highly selective endogenous ligand, it enables researchers to characterize receptor-ligand interactions and downstream signaling events specific to the NOP system. These studies are fundamental for distinguishing the physiological roles of the NOP receptor from those of mu, delta, and kappa opioid receptors, thereby advancing the understanding of receptor selectivity, ligand efficacy, and the broader opioid receptor superfamily.
Pain modulation research: The peptide is a critical tool in dissecting the molecular and cellular mechanisms underlying nociception and pain modulation. Its ability to modulate pain transmission independently of classical opioid pathways allows scientists to explore alternative analgesic mechanisms and the neurochemical basis for pain perception. Investigations utilizing this neuropeptide have shed light on the complex interplay between excitatory and inhibitory neurotransmission in central and peripheral pain circuits, supporting the development of novel hypotheses in pain research.
Neurobehavioral studies: Nociceptin is widely used in behavioral neuroscience to assess its effects on stress, anxiety, learning, and memory. Experimental models incorporating this peptide facilitate the exploration of how the NOP system influences emotional regulation and cognitive processing. Such studies help delineate the neurobiological substrates of stress-related and affective disorders, providing a foundation for understanding the non-opioid modulation of mood and behavior.
Peptide signaling pathway analysis: As a prototypical ligand for the NOP receptor, nociceptin serves as an essential reagent for mapping intracellular signaling cascades activated by peptide-receptor interactions. Researchers utilize it to probe G protein-coupled receptor (GPCR) pathways, second messenger systems, and regulatory feedback mechanisms unique to the NOP system. These analyses contribute to a deeper comprehension of peptide signaling networks in neuronal and non-neuronal tissues, informing broader GPCR research and drug discovery efforts.
Drug discovery and screening: The neuropeptide is integral to in vitro and in vivo screening platforms aimed at identifying novel modulators of the NOP receptor. By serving as a reference agonist, it enables the benchmarking of synthetic ligands, antagonists, and allosteric modulators, thereby facilitating structure-activity relationship studies and the optimization of candidate molecules. Its use in high-throughput screening assays supports the advancement of innovative pharmacological probes targeting the NOP system for basic research and preclinical investigation.
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