Ozarelix is a potent gonadotropin-releasing hormone (GnRH) antagonist used in the biomedical industry for the treatment of prostate cancer. It efficiently inhibits the release of luteinizing hormone and follicle-stimulating hormone, thereby reducing androgen production and suppressing tumor growth. With its targeted action, Ozarelix offers a promising therapeutic solution for patients battling this malignancy.
CAT No: R2000
CAS No:295350-45-7
Synonyms/Alias:Ozarelix;295350-45-7;Ozarelix [INN];UNII-Q1IF8M2YL3;Q1IF8M2YL3;D 63153;DTXSID60183722;D-63153;D-63 153;Ac-D-Nal(2)-D-Phe(4Cl)-D-Pal(3)-Ser-NMe-Tyr-D-Hcit-Nle-Arg-Pro-D-Ala-NH2;D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-N6-(aminocarbonyl)-D-lysyl-L-norleucyl-L-arginyl-L-prolyl-;AC-D-2-NAL-D-4-CPA-D-3-PAL-SER-N-ME-TYR-D-HCI-NLE-ARG-PRO-D-ALA-NH2;AC-D-NAL(2)-D-PCL-D-PAL-SER-N-ME-TYR-D-HOMOCIT-NLE-ARG-PRO-D-ALA-NH2;N-ACETYL-3-(2-NAPHTHALENYL)-D-ALANYL-4-CHLORO-D-PHENYLALANYL-3-(3-PYRIDINYL)-D-ALANYL-L-SERYL-N-METHYL-L-TYROSYL-N6-(AMINOCARBONYL)-D-LYSYL-L-NORLEUCYL-L-ARGINYL-L-PROLYL-D-ALANINAMIDE;ozarelixum;Ozarelix acetate salt;H-Pro-Gly-NH2 . HCl;LHRH antagonist SPI-153;SCHEMBL19712249;DTXCID00106213;SPI-153;DB12581;DA-64267;FO110080;HY-16375;CS-0006308;D63153;D63 153;Q27286888;
Chemical Name:(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]-methylamino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-(carbamoylamino)hexanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
Ozarelix is a synthetic decapeptide that functions as a potent gonadotropin-releasing hormone (GnRH) antagonist, widely recognized for its ability to modulate the hypothalamic-pituitary-gonadal axis. As a member of the peptide compound category, Ozarelix is structurally designed to bind competitively to GnRH receptors, thereby inhibiting the downstream secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Its well-defined mechanism of action and high receptor affinity make it a valuable tool in biochemical and endocrine research, particularly for studies exploring hormonal regulation and feedback mechanisms in vertebrate systems. Owing to its robust antagonistic properties, Ozarelix is frequently utilized in research settings that require precise control of reproductive hormone levels for elucidating physiological and molecular pathways.
Endocrine Signaling Research: In the context of endocrine signaling studies, Ozarelix serves as a precise molecular probe for dissecting the regulatory networks governing gonadotropin release. By effectively blocking GnRH receptor activation, it enables researchers to investigate the downstream consequences of suppressed LH and FSH secretion, offering insights into the physiological roles of these hormones in reproductive biology and related metabolic processes. Its use facilitates the modeling of hypogonadotropic conditions in vitro and in vivo, aiding in the elucidation of compensatory pathways and hormonal feedback loops.
Peptide Receptor Pharmacology: Ozarelix is extensively employed in receptor pharmacology assays to characterize the binding dynamics, specificity, and competitive inhibition of GnRH receptors. Its well-characterized structure and antagonistic potency allow for detailed studies of ligand-receptor interactions, including affinity measurements, receptor occupancy, and the delineation of structure-activity relationships. Such investigations are critical for advancing the understanding of GnRH receptor modulation and for benchmarking the efficacy of novel peptide antagonists or analogs in preclinical research.
Hormonal Regulation Modeling: The compound is utilized to establish experimental models of reversible suppression of gonadotropin signaling. By inducing a controlled and reversible decrease in LH and FSH levels, Ozarelix allows researchers to study the physiological and molecular consequences of gonadotropin deprivation. These models are instrumental in exploring the roles of reproductive hormones in tissue development, cellular signaling, and gene expression, as well as in evaluating the effects of hormonal manipulation on endocrine organ systems.
Peptide Synthesis and Analytical Reference: In peptide chemistry and analytical laboratories, Ozarelix is frequently used as a reference standard or positive control for validating synthetic methodologies and analytical detection techniques. Its defined sequence and robust bioactivity make it a benchmark compound for quality control, assay development, and method validation in the synthesis and characterization of GnRH analogs and related peptide therapeutics. Analytical studies benefit from its predictable chromatographic and spectrometric properties, supporting the development of robust peptide quantification protocols.
Cellular Mechanism Elucidation: The use of Ozarelix in cell-based assays enables the investigation of intracellular signaling cascades initiated by GnRH receptor blockade. Researchers leverage its antagonistic properties to delineate downstream molecular events, such as changes in second messenger systems, transcriptional responses, and protein phosphorylation patterns. These studies contribute to a deeper understanding of how GnRH antagonists modulate cellular physiology, providing a foundation for broader investigations into signal transduction and endocrine regulation at the molecular level.
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