P11

P11 is potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). It can blocks proliferation and induces apoptosis in HUVECs. It exhibits antiangiogenic property.

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CAT No: R0982

CAS No: 848644-86-0

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Specification Technical Data Publications Customer reviews and Q&A
M.F/FormulaC30H48N12O9
M.W/Mr.720.78
SequenceHSDVHK-NH2
Labeling TargetIntegrin
AppearanceCrystalline solid
Purity>98%
ActivityAntagonist
InChIInChI=1S/C30H48N12O9/c1-15(2)24(30(51)40-20(8-17-11-35-14-37-17)27(48)38-19(25(33)46)5-3-4-6-31)42-28(49)21(9-23(44)45)39-29(50)22(12-43)41-26(47)18(32)7-16-10-34-13-36-16/h10-11,13-15,18-22,24,43H,3-9,12,31-32H2,1-2H3,(H2,33,46)(H,34,36)(H,35,37)(H,38,48)(H,39,50)(H,40,51)(H,41,47)(H,42,49)(H,44,45)/t18-,19-,20-,21-,22-,24-/m0/s1
InChI KeyFSVRGWKWZIRBPC-KESUXUJOSA-N
Isomeric SMILESCC(C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CN=CN2)N
References

p11 alone can associate with the plasma membrane in the absence of ANX2 and facilitate plasmin activation and invasiveness in colorectal cancer cells. Upregulation of p11 has been reported in several cancers including renal cell carcinoma, squamous non-cell lung cancer, anaplastic large cell lymphoma, and pediatric intracranial ependymoma. However, the role of the p11 in the development and progression of acute lymphoblastic leukemia has not been intensely investigated.

Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy

1. Glucagonlike peptide 2 analogue teduglutide: stimulation of proliferation but reduction of differentiation in human Caco-2 intestinal epithelial cells

2. The effect of sex on immune responses to a homocitrullinated peptide in the DR4-transgenic mouse model of Rheumatoid Arthritis

3. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment

4. Cationic cell-penetrating peptides are potent furin inhibitors

5. Immune responses to peptides containing homocitrulline or citrulline in the DR4-transgenic mouse model of rheumatoid arthritis

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