PD 173212

L-Tyrosinamide, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)- incorporates bulky aromatic substituents that strongly influence hydrophobic packing. The structure enables studies of steric effects and conformational restriction. Researchers analyze binding determinants and solvent interactions. Applications include synthetic design, structural chemistry, and ligand-scaffold development.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
PD 173212(CAS 217171-01-2)

CAT No: R2336

CAS No:217171-01-2

Synonyms/Alias:L-Tyrosinamide, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)-;217171-01-2;PD 173212;PD173212;Z7UUP5FPKC;PD-173212;UNII-Z7UUP5FPKC;CHEMBL299749;(2S)-N-[(2S)-1-(tert-butylamino)-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]-2-[(4-tert-butylphenyl)methyl-methylamino]-4-methylpentanamide;L-Tyrosinamide, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)-;SCHEMBL8188148;DTXSID10432752;SIA17101;BDBM50078723;AKOS024457680;AT33974;CS-7879;NCGC00347242-02;MS-30611;HY-103318;(S)-2-[(4-tert-Butyl-benzyl)-methyl-amino]-4-methyl-pentanoic acid [(S)-2-(4-benzyloxy-phenyl)-1-tert-butylcarbamoyl-ethyl]-amide;N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)-L-Tyrosinamide;

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M.F/Formula
C38H53N3O3
M.W/Mr.
599.8
Sequence
One Letter Code:LX
Three Letter Code:Bn(4-tBu)-N(Me)Leu-Tyr(Bn)-NHtBu

L-Tyrosinamide, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)- is a highly specialized carbohydrate compound recognized for its unique structural features and functional versatility in advanced biochemical research. Characterized by its tailored sequence of amino acid derivatives and modified side chains, this molecule offers researchers a valuable tool for probing intricate biological processes and developing innovative analytical methodologies. Its design enables precise interactions within complex biological systems, making it a sought-after reagent in various experimental protocols. The compound's stability and compatibility with a range of solvents further enhance its applicability in both in vitro and in situ studies, providing a reliable foundation for experimental reproducibility and data consistency. With its capacity to participate in diverse chemical reactions and its adaptability to custom modifications, L-Tyrosinamide derivatives are increasingly utilized in interdisciplinary scientific investigations spanning from molecular biology to material science.

Peptide Synthesis Research: In the realm of peptide synthesis, L-Tyrosinamide derivatives serve as essential intermediates for constructing complex peptide chains with tailored functionalities. Their unique side chain modifications facilitate selective coupling reactions, enabling the assembly of peptides with specific biological or physicochemical properties. Researchers leverage these compounds to introduce non-standard amino acids or to engineer peptides that exhibit enhanced stability, bioactivity, or resistance to enzymatic degradation. The compound's role as a building block in solid-phase peptide synthesis protocols is particularly valuable for generating libraries of peptide analogs for structure-activity relationship studies.

Enzyme Substrate Development: As a substrate analog, this carbohydrate compound is instrumental in the design and evaluation of enzyme assays, particularly those targeting proteases and peptidases. Its modified backbone and side chains allow for the fine-tuning of substrate specificity, providing insights into enzyme-substrate interactions and catalytic mechanisms. By incorporating the compound into assay systems, researchers can monitor enzymatic activity, identify inhibitors, and characterize the kinetic properties of novel enzymes, thereby advancing the understanding of protein function and regulation in biological systems.

Bioconjugation Strategies: The structural attributes of L-Tyrosinamide derivatives make them ideal candidates for bioconjugation applications, where they serve as linkers or functional groups for attaching biomolecules, fluorescent probes, or affinity tags. Their chemical reactivity enables the formation of stable covalent bonds with various biomolecular targets, facilitating the creation of conjugates for imaging, detection, and purification purposes. This application is particularly relevant in the development of targeted delivery systems, biosensors, and diagnostic tools, where specificity and stability are paramount.

Structural Biology Studies: In structural biology, modified tyrosinamide compounds are employed as molecular probes to investigate protein-ligand interactions and conformational dynamics. Their ability to mimic natural substrates or inhibitors allows researchers to dissect binding mechanisms and elucidate the structural determinants of molecular recognition. Crystallographic and spectroscopic analyses utilizing these compounds contribute to the rational design of novel ligands and the optimization of protein engineering strategies, ultimately enhancing our understanding of biomolecular architecture and function.

Material Science Research: The versatility of L-Tyrosinamide, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)- extends to material science, where it is incorporated into the synthesis of functionalized polymers and nanomaterials. Its unique chemical structure imparts desirable properties such as improved biocompatibility, tunable hydrophobicity, and enhanced mechanical strength to the resulting materials. Researchers exploit these characteristics to develop advanced coatings, hydrogels, and nanocarriers for applications ranging from biomedical engineering to environmental remediation, demonstrating the compound's impact beyond traditional biochemical research. Collectively, these diverse application directions underscore the scientific value and versatility of this carbohydrate compound, positioning it as an indispensable resource for researchers seeking to advance knowledge and innovation across multiple disciplines.

InChI
InChI=1S/C38H53N3O3/c1-27(2)23-34(41(9)25-29-15-19-31(20-16-29)37(3,4)5)36(43)39-33(35(42)40-38(6,7)8)24-28-17-21-32(22-18-28)44-26-30-13-11-10-12-14-30/h10-22,27,33-34H,23-26H2,1-9H3,(H,39,43)(H,40,42)/t33-,34-/m0/s1
InChI Key
GCDHMGROXQUFNR-HEVIKAOCSA-N

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