Solnatide is an astounding peptide-based therapeutic agent exclusively utilized in the expansive biomedical arena. Its unparalleled efficacy lies in its profound anti-inflammatory and anti-edematous characteristics, meticulously enhancing pulmonary performance through its precise modulation of epithelial sodium channels (ENaC) while substantially mitigating lung fluid accumulation.
CAT No: R1993
CAS No:259206-53-6
Synonyms/Alias:Solnatide;259206-53-6;Solnatide [INN];TIP-peptide;UNII-17ZS80333G;AP301 peptide;AP-301;EX-A7494;17ZS80333G;Cys-gly-gln-arg-glu-thr-pro-glu-gly-ala-glu-ala-lys-pro-trp-tyr-cys cyclic (1->17)-disulfide;DA-67689;L-Cysteine, L-cysteinylglycyl-L-glutaminyl-L-arginyl-L-alpha-glutamyl-L-threonyl-L-prolyl-L-alpha-glutamylglycyl-L-alanyl-L-alpha-glutamyl-L-alanyl-L-lysyl-L-prolyl-L-tryptophyl-L-tyrosyl-, cyclic (1->17)-disulfide;L-Cysteine, L-cysteinylglycyl-L-glutaminyl-L-arginyl-L-alpha-glutamyl-L-threonyl-L-prolyl-L-alpha-glutamylglycyl-L-alanyl-L-alpha-glutamyl-L-alanyl-L-lysyl-L-prolyl-L-tryptophyl-L-tyrosyl-, cyclic (1-->17)-disulfide;
Chemical Name:(3S,6S,9S,12S,18S,21S,27S,30S,33S,36S,42R,47R,50S,53S,56S)-42-amino-3-(4-aminobutyl)-36-(3-amino-3-oxopropyl)-33-(3-carbamimidamidopropyl)-9,18,30-tris(2-carboxyethyl)-27-[(1R)-1-hydroxyethyl]-50-[(4-hydroxyphenyl)methyl]-53-(1H-indol-3-ylmethyl)-6,12-dimethyl-2,5,8,11,14,17,20,26,29,32,35,38,41,49,52,55-hexadecaoxo-44,45-dithia-1,4,7,10,13,16,19,25,28,31,34,37,40,48,51,54-hexadecazatricyclo[54.3.0.021,25]nonapentacontane-47-carboxylic acid
Solnatide is a synthetic peptide compound designed to modulate pulmonary epithelial barrier function and regulate alveolar fluid clearance. As a bioactive peptide, it mimics a specific domain of the human tumor necrosis factor (TNF) receptor and interacts with the epithelial sodium channel (ENaC), making it an important research tool for investigating respiratory physiology and pathophysiology. Its unique sequence and mechanism of action have attracted significant attention in the fields of pulmonary biology, peptide signaling, and membrane protein modulation, providing scientists with a robust platform for studying cellular transport processes and barrier integrity in vitro and in vivo. The compound's stability, defined peptide structure, and targeted activity enable precise experimental manipulation in a variety of advanced biochemical and physiological research settings.
Pulmonary epithelial transport research: Solnatide is widely employed in studies investigating the mechanisms of alveolar fluid clearance and sodium ion transport across pulmonary epithelial cells. By interacting directly with ENaC, it enhances sodium uptake, thereby facilitating water reabsorption from the alveolar space. Researchers utilize this peptide to dissect the molecular pathways governing ion channel regulation, epithelial permeability, and fluid homeostasis in both normal and injury models, contributing to a deeper understanding of lung fluid dynamics and barrier function.
Acute lung injury and edema modeling: The peptide serves as a valuable agent in experimental models of acute lung injury (ALI) and pulmonary edema, where it is used to evaluate the modulation of epithelial barrier properties. Its ability to influence ENaC activity allows investigators to simulate and analyze the resolution of edema, track changes in alveolar-capillary permeability, and assess the restoration of fluid balance under pathological conditions. These studies provide critical insights into the molecular underpinnings of lung injury and repair processes.
Peptide signaling and receptor interaction studies: As a synthetic analog of a TNF receptor domain, solnatide is instrumental in probing peptide-receptor interactions and downstream signaling pathways. It offers a controlled system to explore how peptide ligands modulate membrane protein conformation, trigger intracellular signaling cascades, and influence cell surface receptor function. Such research advances the broader understanding of peptide-based modulation of cellular responses in epithelial and endothelial systems.
Membrane protein pharmacology: The compound's specificity for ENaC makes it a powerful tool for characterizing the pharmacological properties of epithelial sodium channels. In electrophysiological assays and high-throughput screening platforms, solnatide is used to elucidate channel gating mechanisms, test the efficacy of channel modulators, and investigate the impact of peptide-based interventions on ion transport. These applications support the discovery and validation of novel modulators of epithelial transport relevant to respiratory and renal physiology.
Peptide engineering and structure-activity relationship (SAR) analysis: The defined sequence and activity profile of solnatide provide an excellent template for peptide engineering and SAR studies. Researchers leverage its structure to design and synthesize analogs with altered activity, stability, or receptor affinity, facilitating the optimization of peptide-based modulators for experimental use. Such investigations expand the toolkit for probing peptide-protein interactions and contribute to the development of next-generation research reagents targeting epithelial ion channels.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More