trans-4-Hydroxy-L-proline is a naturally occurring, non-proteinogenic-type proline derivative featuring a pyrrolidine ring bearing a hydroxyl substituent at the 4-position and a trans relationship between the ring and side-chain substituents, with L stereochemistry indicated in the name. The molecule contains a free amino group and a carboxyl group along with a secondary alcohol side chain that can participate in hydrogen bonding and can be chemically modified for conjugation or protection during peptide assembly. As a conformationally constrained hydroxyproline analogue, it is used in peptide synthesis and structure-activity or protein-structure studies to introduce hydroxyl-bearing proline-like residues and to support studies of how side-chain functionality and stereochemistry influence amide formation and peptide conformation.
CAT No: CP01101
CAS No:51-35-4
Synonyms/Alias:trans-4-Hydroxy-L-proline;L-Hydroxyproline;hydroxyproline;51-35-4;(2S,4R)-4-Hydroxypyrrolidine-2-carboxylicacid;trans-4-Hydroxyproline;hydroxy-L-proline;L-4-hydroxyproline;Hypro;trans-L-Hydroxyproline;Ls-Hydroxyproline;trans-Hydroxyproline;4-L-Hydroxyproline;4-Hydroxy-L-proline;4-hydroxyproline;4-Hydroxy-2-pyrrolidinecarboxylicacid;H-Hyp-OH;hydroxiproline;hydroxy-proline;(4r)-4-hydroxy-l-prolin;h-l-hyp-oh;(4R)-4-hydroxy-L-proline;delta-Hydroxyproline;l-trans-hydroxyproline;Hydroxyproline(VAN)
3. Store-operated Ca2+ entry sustains the fertilization Ca2+ signal in pig eggs
5. TMEM16F and dynamins control expansive plasma membrane reservoirs
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