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UP_P69746

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: X19322

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
Sequence
CCGVPNAACHPCVCKNTC
Functions
Alpha-A-short conotoxins act on postsynaptic membranes, they selectively bind to the fetal (alpha1 beta1 gamma delta subunits) mammalian muscle nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks the fetal muscle subtype (IC(50)=0.51 nM) with 600-fold greater affinity than the adult subtype (IC(50)=310 nM). It blocks the elicited currents completely, and it dissociates very slowly from the fetal muscle receptor. Has no inhibitory activity on various neuronal nAChRs. This toxin causes an apparently irreversible paralysis upon intramuscular injection into gold fish.
Source#
Synthetic
Solubility
-20°C

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