ACV 1

ACV 1 is neuronal nicotinic receptor antagonist that displays selectivity for the α9α10 subtype. It can alleviates neuropathic pain in three rat models of human neuropathic pain and accelerate functional recovery of injured neurons.

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CAT No: R0866

CAS No: 740980-24-9

Synonyms/Alias: Conotoxin Vc1.1

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Specification Technical Data Publications Customer reviews and Q&A
M.F/FormulaC71H103N23O25S4
M.W/Mr.1806.98
SequenceGCCSDPRCNYDHPEIC-NH2(Disulfide bridge between Cys2 and Cys8, Cys3 and Cys16)
Labeling TargetNeuronal nicotinic receptor
Purity>99 %
ActivityAntagonist
Solubility-20°C
InChIInChI=1S/C71H103N23O25S4/c1-3-32(2)55-68(117)89-44(56(74)105)27-120-122-30-47-65(114)88-43(26-95)62(111)87-42(23-54(103)104)70(119)94-18-6-8-48(94)66(115)81-36(7-4-16-78-71(75)76)57(106)90-46(29-123-121-28-45(63(112)91-47)80-51(98)24-72)64(113)84-39(21-50(73)97)60(109)83-38(19-33-10-12-35(96)13-11-33)59(108)85-40(22-53(101)102)61(110)86-41(20-34-25-77-31-79-34)69(118)93-17-5-9-49(93)67(116)82-37(58(107)92-55)14-15-52(99)100/h10-13,25,31-32,36-49,55,95-96H,3-9,14-24,26-30,72H2,1-2H3,(H2,73,97)(H2,74,105)(H,77,79)(H,80,98)(H,81,115)(H,82,116)(H,83,109)(H,84,113)(H,85,108)(H,86,110)(H,87,111)(H,88,114)(H,89,117)(H,90,106)(H,91,112)(H,92,107)(H,99,100)(H,101,102)(H,103,104)(H4,75,76,78)
InChI KeyKJQOYUHYAZGPIZ-UHFFFAOYSA-N
BoilingPointN/A
Melting PointN/A

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    Angiotensin II human (Angiotensin II) is a vasoconstrictor that mainly acts on the AT1 receptor. Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis.

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