AdTx1

AdTx1 is a 65 amino-acid peptide and a selective, high affinity, non-competitive α1A adrenoceptor antagonist (Ki = 0.35 nM). It exhibits no significant activity against a range of other GPCRs, including α2A, β1 and β2 adrenoceptors. AdTx1 is used as a potent relaxant of smooth muscles.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: R1044

Synonyms/Alias:ρ-Da1a

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C310H481N87O100S8
M.W/Mr.
7283.22
Sequence
LTCVTSKSIFGITTEDCPDGQNLCFKRRHYVVPKIYDSTRGCAATCPIPENYDSIHCCKTDKCNE(Modifications: Disulfide bridge: 3-24, 17-42, 46-57, 58-63)
Labeling Target
α1A adrenoceptor
Appearance
Lyophilized solid
Purity
>98%
Activity
Antagonist
Source#
Synthetic
Long-term Storage Conditions
Soluble in water

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