AdTx1

AdTx1 is a 65 amino-acid peptide and a selective, high affinity, non-competitive α1A adrenoceptor antagonist (Ki = 0.35 nM). It exhibits no significant activity against a range of other GPCRs, including α2A, β1 and β2 adrenoceptors. AdTx1 is used as a potent relaxant of smooth muscles.

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CAT#R1044
Synonyms/Aliasρ-Da1a
M.F/FormulaC310H481N87O100S8
M.W/Mr.7283.22
SequenceLTCVTSKSIFGITTEDCPDGQNLCFKRRHYVVPKIYDSTRGCAATCPIPENYDSIHCCKTDKCNE(Modifications: Disulfide bridge: 3-24, 17-42, 46-57, 58-63)
Labeling Targetα1A adrenoceptor
AppearanceLyophilized solid
Purity>98%
ActivityAntagonist
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