Aloc-Ala-OH · DCHA is an N-ALOC-protected alanine derivative provided as a dicyclohexylamine (DCHA) salt, where the alanine backbone bears a free carboxylic acid (-COOH) and an amide/amine functionality masked by the allyloxycarbonyl (Alloc) protecting group. The molecule contains an amino acid side chain with a methyl group (-CH3) and, in its protected form, the nitrogen is protected to control chemoselectivity during stepwise peptide assembly while the carboxyl group remains available for coupling. As an Alloc-protected amino acid salt, it is used as a building block in peptide synthesis workflows, including solid-phase or solution-phase strategies that require orthogonal deprotection of the Alloc group to expose the amine for subsequent bond formation.
Aloc-Ala-OH · DCHA is an alanine derivative bearing an Aloc (allyloxycarbonyl) protecting group on the amino functionality and a free carboxylic acid for downstream coupling. Supplied as a DCHA salt, this form is commonly used to improve handling and reproducibility in peptide and intermediate synthesis workflows where controlled deprotection and reliable reactivity are required. The stereochemical information corresponds to alanine, providing a straightforward backbone building block for assembling short peptides and protected amino acid segments.
1. Solid-Phase Peptide Building
Aloc-Ala-OH · DCHA is used by peptide synthesis groups to incorporate an alanine residue into peptide chains during solid-phase peptide synthesis, where the Aloc group supports orthogonal protection strategies relative to other common protecting groups. Researchers typically select this reagent when they want a well-defined amino acid building block that can be introduced as a protected residue while maintaining a free carboxylic acid for coupling chemistry. The DCHA salt form is particularly valued in routine peptide workflows for consistent weighing, improved material handling, and reproducible performance across synthesis batches.
2. Orthogonal Deprotection Strategy
Aloc-Ala-OH · DCHA supports synthetic planning in laboratories that rely on stepwise, orthogonal deprotection schedules for complex peptide or peptidomimetic assembly. The Aloc protecting group is leveraged to enable selective removal under conditions compatible with other functionalities present in the growing peptide or intermediate, helping teams manage protecting-group compatibility during multi-step synthesis campaigns. Medicinal chemistry and chemical biology groups frequently choose this reagent when they need a protected alanine segment that integrates cleanly into their existing protecting-group logic without forcing changes to the broader synthesis route.
3. Pharmaceutical Intermediate Assembly
Aloc-Ala-OH · DCHA is also used as a protected alanine intermediate for the preparation of defined peptide fragments and amino acid-containing intermediates in pharmaceutical intermediate development. Process and R&D chemists use this material to build toward larger, more complex structures where controlled deprotection and reliable coupling of an alanine unit are required before advancing to downstream functionalization or final assembly steps. The combination of a protected amino group with a free carboxylic acid makes it a practical building block for constructing peptide-like scaffolds and related intermediates used in drug discovery chemistry programs.
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