BAM-22P, a highly potent opioid peptide, is a potent opioid agonist.
CAT No: R1233
CAS No:76622-26-9
Synonyms/Alias:Bam-22P;76622-26-9;Bam 22P;Leucine-enkephalin, arg-arg-val-gly-arg-pro-glu-trp-trp-met-asp-tyr-gly-;DTXSID40227451;Arg-arg-val-gly-arg-pro-glu-trp-trp-met-asp-tyr-gly-lys-arg-tyr-gly-leu-enkephalin;Leu-enkephalin, arg-arg-val-gly-arg-pro-glu-trp-trp-met-asp-tyr-gly-lys-arg-tyr-gly-;Met-enkephalin-arg-arg-val-gly-arg-pro-glu-trp-trp-met-asp-tyr-gln-lys-arg-tyr-gly-;Glycine, L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-L-valylglycyl-L-arginyl-L-prolyl-L-alpha-glutamyl-L-tryptophyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-arginyl-L-tyrosyl-;MFCD00076690;DTXCID40149942;AKOS024456725;DA-71284;PD079103;BAM-22P (H-L-Tyr-Gly-Gly-L-Phe-L-Met-L-Arg-L-Arg-L-Val-Gly-L-Arg-L-Pro-L-Glu-L-Trp-L-Trp-L-Met-L-Asp-L-Tyr-L-Gln-L-Lys-L-Arg-L-Tyr-Gly-OH);
BAM-22P, also known as Bovine Adrenal Medulla peptide 22, is a synthetic peptide that functions as a biologically active fragment derived from proenkephalin A. As a member of the opioid peptide family, BAM-22P is distinguished by its potent affinity for both opioid and non-opioid receptors, contributing to its significance in neurobiological and pharmacological research. Its well-characterized sequence and robust receptor binding properties make it a valuable tool for dissecting the molecular mechanisms underlying pain modulation, neuropeptide signaling, and receptor-ligand interactions in various experimental models.
Receptor binding studies: BAM-22P is widely utilized in receptor binding assays to elucidate the pharmacological profiles of opioid and related receptors. Its high affinity for μ- and δ-opioid receptors, as well as certain non-opioid sites, enables researchers to map receptor distribution, characterize ligand specificity, and investigate competitive binding dynamics. These applications are instrumental in advancing the understanding of receptor-ligand interactions and contribute to the development of novel compounds with targeted activity profiles.
Neuropharmacology research: The peptide serves as a critical probe for exploring the complex role of endogenous opioid systems in the central and peripheral nervous systems. By applying BAM-22P in in vitro or ex vivo preparations, investigators can assess its impact on neuronal excitability, synaptic transmission, and neurotransmitter release. Such studies provide valuable insights into the modulation of pain pathways, stress responses, and neuroendocrine regulation, supporting the broader field of neuropeptide signaling research.
Peptide structure-activity relationship (SAR) analysis: BAM-22P is frequently employed as a reference compound in SAR studies to delineate the structural determinants of opioid peptide activity. Through systematic modifications of its amino acid sequence, researchers can evaluate how specific residues influence receptor affinity, potency, and selectivity. These investigations not only deepen the mechanistic understanding of peptide-receptor interactions but also inform the rational design of new peptide analogs with optimized biological properties.
Intracellular signaling investigations: The application of BAM-22P in cellular assays enables the examination of downstream signaling cascades triggered by receptor activation. By monitoring second messenger systems, such as cyclic AMP or intracellular calcium flux, scientists can delineate the pathways engaged upon peptide binding. These studies are essential for identifying signal transduction mechanisms associated with opioid and non-opioid receptor activation, thereby expanding knowledge of cellular responses to neuropeptides.
Peptide-based assay development: BAM-22P is also valuable in the development and validation of bioanalytical assays designed to quantify opioid peptide activity or screen for receptor modulators. Its well-defined pharmacological profile makes it an ideal standard or positive control in functional assays, including those based on receptor activation, signal transduction, or ligand competition. These applications support the advancement of high-throughput screening platforms and facilitate the identification of novel compounds targeting opioid and related signaling pathways.
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