BigLEN (mouse) is a neuropeptide containing aromatic, hydrophobic, and charged residues that encourage dynamic structural shifts. Researchers use it to analyze peptide-protein interfaces, secondary-structure transitions, and solvent effects. The sequence's modular design supports advanced conformational studies. Its residue pattern promotes detailed biophysical evaluation.
CAT No: R2321
CAS No:501036-69-7
Synonyms/Alias:501036-69-7;BigLEN (mouse);L-Proline,L-leucyl-L-a-glutamyl-L-asparaginyl-L-prolyl-L-seryl-L-prolyl-L-glutaminyl-L-alanyl-L-prolyl-L-alanyl-L-arginyl-L-arginyl-L-leucyl-L-leucyl-L-prolyl-;AKOS032962862;PD080170;
BigLEN (mouse) is a synthetic peptide corresponding to the endogenous ligand for the G protein-coupled receptor GPR171, originally identified in murine brain tissue. As a member of the neuropeptide family, BigLEN is derived from the proSAAS precursor and is recognized for its role in modulating neuronal signaling pathways. Its functional attributes have attracted significant interest in neurobiology, peptide signaling research, and the study of ligand-receptor interactions. The availability of synthetic BigLEN allows researchers to dissect its biological roles in controlled experimental systems, advancing understanding of neuropeptide function in mammalian models.
Receptor pharmacology: BigLEN serves as a highly specific tool for investigating the pharmacological characteristics of GPR171. By applying this peptide in in vitro or ex vivo systems, researchers can characterize ligand-receptor binding affinities, downstream signaling cascades, and receptor activation profiles. Such studies are essential for elucidating the molecular mechanisms underlying GPR171-mediated signaling and for identifying potential modulators or antagonists in neuropeptide research.
Neurobiology research: The peptide is widely utilized in studies exploring neuropeptide regulation of synaptic transmission, neuronal excitability, and behavioral phenotypes in rodent models. By administering BigLEN to neuronal cultures or brain slices, scientists can probe its effects on neurotransmitter release, neural circuit modulation, and plasticity. These experiments provide critical insights into how endogenous peptides influence central nervous system function and behavior.
Peptide signaling pathway analysis: BigLEN is instrumental in dissecting the intracellular pathways activated upon GPR171 engagement. Its use enables the mapping of downstream effectors such as second messengers, kinases, and transcription factors involved in neuropeptide signaling. This application is particularly valuable for identifying cross-talk with other signaling networks and for understanding the broader physiological roles of peptide-GPCR systems.
Structure-function studies: The synthetic availability of BigLEN allows for detailed structure-activity relationship (SAR) investigations. By employing native or modified peptide analogs, researchers can determine which amino acid residues are critical for receptor binding and activation. Such studies inform the rational design of selective agonists or antagonists, facilitating the development of novel research tools and advancing peptide-based probe design.
Peptide quantification and assay development: BigLEN is also employed as a reference standard or control in the development and validation of quantitative assays, such as enzyme-linked immunosorbent assays (ELISAs) or mass spectrometry-based detection methods. Utilizing the peptide in assay calibration supports the accurate measurement of endogenous BigLEN levels in biological samples, enabling robust quantification in neurochemical and physiological studies.
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