Bz-Nle-Lys-Arg-Arg-AMC

Substrate for dengue virus NS2B-NS3 and yellow fever virus NS3 protease. The kcat/Km value of Bz-NleKRR-AMC for the dengue virus type 4 (DEN4) enzyme is > 800 fold higher than that of Boc-Gly-Arg-Arg-AMC, a widely used NS3 substrate (kcat = 2.9 s⁻¹, Km = 8.6 μM for DEN4). For yellow fever virus NS3 protease the kcat value was 0.111 s⁻¹, the Km value 14.6 μM.

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CAT No: R1920

CAS No: 863975-32-0

Synonyms/Alias: Bz-Nle-Lys-Arg-Arg-AMC;863975-32-0;Bz-Nle-KRR-AMC (hydrochloride);Bz-Nle-Lys-Arg-Arg-AMC.HCl;N-[(2S)-1-[[(2S)-6-amino-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]benzamide;hydrochloride;

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Specification Technical Data Publications Customer reviews and Q&A
M.F/FormulaC41H61ClN12O7
M.W/Mr.869.5
SequenceOne Letter Code:XKRR
Three Letter Code:Bz-Nle-Lys-Arg-Arg-AMC.HCl
ApplicationVirology
Long-term Storage ConditionsSoluble in DMSO
InChIInChI=1S/C41H60N12O7.ClH/c1-3-4-14-29(50-35(55)26-12-6-5-7-13-26)37(57)51-30(15-8-9-20-42)38(58)53-32(17-11-22-48-41(45)46)39(59)52-31(16-10-21-47-40(43)44)36(56)49-27-18-19-28-25(2)23-34(54)60-33(28)24-27;/h5-7,12-13,18-19,23-24,29-32H,3-4,8-11,14-17,20-22,42H2,1-2H3,(H,49,56)(H,50,55)(H,51,57)(H,52,59)(H,53,58)(H4,43,44,47)(H4,45,46,48);1H/t29-,30-,31-,32-;/m0./s1
InChI KeyDINNPVBPBDJKQJ-WYDLTDSDSA-N

1. Characterization of Novel P-Selectin Targeted Complement Inhibitors in Murine Models of Hindlimb Injury and Transplantation

2. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function

3. Sex differences in oxidative stress level and antioxidative enzymes expression and activity in obese pre-diabetic elderly rats treated with metformin or liraglutide

4. Multifunctional peptide-oligonucleotide conjugate promoted sensitive electrochemical biosensing of cardiac troponin I

5. Quantitative Analysis of Ligands Effects on Bioefficacy of Nanoemulsion encapsulating Depigmenting Active

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