Calcitonin (8-32), salmon is a highly selective amylin receptor antagonist.
CAT No: R1260
CAS No:155069-90-2
Synonyms/Alias:155069-90-2;Calcitonin (8-32), salmon;Calcitonin (8-32) (salmon I) trifluoroacetate salt;8-32-Calcitonin(salmonreduced);8-32-Calcitonin (salmon reduced);DA-51538;FC109515;G12621;H-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-TyrPro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH? trifluoroacetate salt;
Calcitonin (8-32), salmon is a synthetic peptide fragment derived from the native salmon calcitonin hormone, specifically encompassing residues 8 through 32 of the full-length peptide. As a well-characterized calcitonin receptor antagonist, this compound plays a significant role in modulating the biological activity of calcitonin and related signaling pathways. Its unique sequence and high affinity for the calcitonin receptor make it a valuable molecular tool for dissecting the physiological and pharmacological roles of calcitonin in various cellular and tissue-based systems. The use of this peptide fragment enables researchers to selectively inhibit calcitonin-mediated responses, facilitating a deeper understanding of bone metabolism, calcium homeostasis, and peptide hormone signaling.
Receptor binding studies: Calcitonin (8-32), salmon is widely employed in receptor binding assays to characterize the specificity and affinity of calcitonin receptors. By competitively inhibiting the binding of native calcitonin, the peptide fragment enables detailed mapping of receptor-ligand interactions and assists in the identification of receptor subtypes. These studies are fundamental for elucidating the molecular mechanisms governing peptide hormone recognition and signal transduction, providing valuable insights for both basic research and the development of receptor-targeted compounds.
Signal transduction research: As a potent antagonist of the calcitonin receptor, this peptide is instrumental in investigations of downstream signaling pathways activated by calcitonin. By blocking receptor activation, it allows researchers to delineate the specific cascades and second messenger systems involved in calcitonin-mediated cellular responses. Such studies are critical for understanding the broader physiological roles of calcitonin signaling in target tissues, including osteoclasts, osteoblasts, and renal cells.
Bone metabolism studies: The use of calcitonin (8-32), salmon in bone biology research enables selective inhibition of calcitonin's effects on bone resorption and formation. In vitro and ex vivo models utilize the peptide to dissect the contribution of endogenous calcitonin to osteoclast activity, bone mineralization, and calcium flux. This approach is essential for unraveling the complex regulation of bone turnover and for validating new targets within skeletal homeostasis pathways.
Peptide structure-activity analysis: The defined sequence of this fragment makes it a valuable tool for structure-activity relationship (SAR) studies within the calcitonin family of peptides. By comparing the biological effects and receptor interactions of different calcitonin fragments, researchers can identify crucial residues responsible for receptor binding and antagonism. Such SAR investigations inform the rational design of novel peptide analogs with tailored biological properties and improved selectivity.
Peptide-based assay development: Calcitonin (8-32), salmon serves as a reference antagonist in the development and validation of bioassays designed to measure calcitonin receptor function. Its well-documented inhibitory activity allows for the establishment of robust assay controls and supports the screening of small molecules or peptides that modulate the calcitonin signaling axis. These assay systems are indispensable for advancing pharmacological research and for exploring the therapeutic modulation of peptide hormone pathways in preclinical settings.
3. An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum
4. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More