Caloxin 2A1 (TFA) is a peptide analog with hydrophobic and polar residues arranged for selective structural interactions. Researchers use it to examine ligand-driven conformational shifts, hydrogen bonding, and protein-interface dynamics. Its sequence supports exploration of secondary-structure modulation. TFA salt form promotes consistent solubility.
CAT No: R2284
CAS No:350670-85-8
Synonyms/Alias:Caloxin 2A1 (TFA);350670-85-8;Caloxin 2A1 Trifluoroacetate;Caloxin 2A1 trifluoroacetate salt;MFCD32666238;Caloxin 2A1 TFA;HY-P3278A;DA-71884;FC111125;MS-32202;CS-0188742;G17187;H-Val-Ser-Asn-Ser-Asn-Trp-Pro-Ser-Phe-Pro-Ser-Ser-Gly-Gly-Gly-NH2; H-VSNSNWPSFPSSGGG-NH2;
Caloxin 2A1 (TFA) is a synthetic peptide inhibitor specifically designed to target and modulate the activity of plasma membrane Ca2+-ATPases (PMCAs). As a member of the caloxin family, it is structurally engineered to interact with extracellular domains of PMCA isoforms, making it a valuable tool for dissecting the regulation of calcium homeostasis in cellular systems. Its trifluoroacetate (TFA) salt form enhances solubility and handling characteristics, facilitating its use in a range of biochemical and physiological investigations. Owing to its selectivity and peptide-based design, Caloxin 2A1 (TFA) has become an important research reagent in studies aiming to elucidate the dynamic control of intracellular calcium levels and related signaling events.
Calcium signaling research: In the context of calcium signaling, Caloxin 2A1 (TFA) provides a precise means to inhibit PMCA activity at the cell surface, allowing researchers to study the downstream effects of altered calcium extrusion. By selectively blocking PMCA-mediated calcium transport, this peptide enables detailed analysis of intracellular calcium dynamics, signal transduction pathways, and the interplay between calcium efflux and cellular responses. Its application is particularly valuable in experiments seeking to differentiate the roles of various calcium transporters and to map the consequences of PMCA inhibition on cellular physiology.
Membrane protein functional studies: The specificity of Caloxin 2A1 (TFA) toward PMCA isoforms makes it a powerful tool for probing the structure-function relationships of these membrane proteins. By applying the inhibitor in controlled settings, scientists can investigate the contribution of individual PMCA variants to overall calcium homeostasis and dissect their interactions with regulatory molecules. Such studies advance the understanding of PMCA's physiological roles and inform the design of further experiments targeting membrane-associated calcium transport mechanisms.
Peptide inhibitor characterization: As a well-defined synthetic peptide, Caloxin 2A1 (TFA) serves as an exemplary model for characterizing peptide-based inhibitors of ion transporters. Its use supports the evaluation of structure-activity relationships, binding affinities, and inhibitory kinetics against PMCA targets. Researchers engaged in the development of next-generation peptide modulators can employ it as a benchmark to assess potency, selectivity, and mechanism of action, thereby contributing to the refinement of peptide inhibitor design strategies.
Cellular model development: The ability of Caloxin 2A1 (TFA) to modulate calcium extrusion makes it suitable for generating cellular models with altered calcium handling capabilities. By applying the peptide to cultured cells or tissue preparations, investigators can induce specific perturbations in calcium homeostasis, which are instrumental for modeling pathophysiological conditions, studying compensatory mechanisms, or validating hypotheses regarding calcium-dependent cellular processes. Such models are essential for advancing fundamental research in cell biology and physiology.
Analytical assay optimization: In biochemical assay development, Caloxin 2A1 (TFA) is employed to validate and optimize methods for measuring PMCA activity and calcium transport. Its selective inhibitory action allows for the establishment of assay baselines, the assessment of assay specificity, and the evaluation of potential off-target effects in complex biological samples. The peptide's inclusion in assay protocols enhances the reliability and interpretability of experimental outcomes, supporting robust data generation in calcium transporter research.
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