Colistin A contains a lipopeptide framework rich in cationic residues that mediate membrane binding and charge-dependent interactions. Cyclic elements promote conformational stability. Researchers explore lipid-association dynamics and folding behavior. Applications include antimicrobial-peptide modeling, biophysical studies, and structure-activity analysis.
CAT No: R2715
CAS No:7722-44-3
Synonyms/Alias:Colistin A;7722-44-3;UNII-500HI50Z9H;500HI50Z9H;COLISTIN A [MI];BRN 0604503;COLISTIN A [WHO-DD];CHEMBL3781027;DTXSID5049079;DTXCID001030474;(6S)-N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;Colistin A Sulfate Hydrate (~90%);(S)-N-((S)-4-amino-1-(((2S,3R)-1-(((S)-4-amino-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-((R)-1-hydroxyethyl)-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)amino)-3-hydroxy-1-oxobutan-2-yl)amino)-1-oxobutan-2-yl)-6-methyloctanamide;L-Threonine, N2-(6-methyl-1-oxooctyl)-L-2,4-diaminobutanoyl-L-threonyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-D-leucyl-L-leucyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-, cyclic (10-4)-peptide;1,4,7,10,13,16,19-Heptaazacyclotricosane;NCGC00161620-01;Colistin A sulfate hydrate;SCHEMBL21476977;HY-P2123;Tox21_113638;BDBM50548038;DA-52020;CAS-7722-44-3;CS-0108900;
Colistin A is a cyclic polypeptide antibiotic belonging to the polymyxin family, recognized for its distinctive amphipathic structure and potent activity against Gram-negative bacteria. As a cationic peptide, it interacts strongly with the lipopolysaccharide components of bacterial membranes, leading to membrane disruption and cell death. Its unique mode of action and selective affinity for bacterial outer membranes have made it a valuable biochemical tool in microbiological research, membrane biology, and studies of antimicrobial mechanisms. Colistin A is widely utilized in academic, industrial, and applied research settings to probe bacterial physiology, resistance mechanisms, and membrane dynamics.
Antimicrobial mechanism studies: Colistin A is extensively employed to investigate the molecular basis of antimicrobial action against Gram-negative organisms. Its interaction with bacterial outer membranes provides a model system for elucidating the biophysical and biochemical processes underlying membrane permeabilization and lysis. Researchers use it to dissect the sequence of events leading to cell death, analyze resistance development, and characterize adaptive responses in microbial populations. These studies are critical for understanding the principles of antibiotic function and for guiding the rational design of next-generation antimicrobial agents.
Membrane biology research: The compound's ability to selectively bind and disrupt the lipid A component of lipopolysaccharides makes it an important probe in membrane biochemistry. Colistin A is applied to study the structure, composition, and functional integrity of bacterial membranes, allowing researchers to assess membrane permeability, lipid organization, and the effects of environmental stressors. Its use in model membrane systems facilitates the exploration of peptide-lipid interactions, providing insights into fundamental aspects of membrane dynamics and stability.
Resistance mechanism exploration: Colistin A serves as a reference compound for characterizing and quantifying bacterial resistance mechanisms, particularly those involving modifications of the outer membrane or efflux systems. By applying the peptide in controlled experimental settings, researchers can monitor phenotypic and genotypic changes associated with reduced susceptibility, such as alterations in lipid A or the expression of resistance genes like mcr-1. These investigations are essential for mapping evolutionary pathways of resistance and for developing molecular diagnostics and surveillance strategies.
Analytical and assay development: The compound is incorporated into a variety of microbiological assays to evaluate the susceptibility of bacterial isolates and to benchmark the performance of novel antimicrobial agents. Its well-characterized activity profile makes it a standard reference in broth microdilution, disk diffusion, and other susceptibility testing formats. Laboratories rely on its consistent effects to validate assay protocols, calibrate instrumentation, and ensure reproducibility in antimicrobial screening workflows.
Biotechnological and synthetic biology applications: Owing to its defined structure and mechanism, Colistin A is utilized in synthetic biology and biotechnological research to engineer bacterial strains with altered membrane properties or enhanced resistance profiles. It is used as a selective agent in genetic manipulation experiments, facilitating the screening and isolation of recombinant strains. Additionally, its role in membrane perturbation studies supports the development of biosensors and membrane-targeted delivery systems, expanding the toolkit available for innovative applications in microbial engineering and applied microbiology.
2. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment
4. C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More