Cortistatin-14 expressed in the cortex and hippocampus. Structural and functional similarities to somatostatin-14. Neuronal depressant and sleep-modulating properties in vivo. An important mediator of immunity and inflammation.
CAT No: 10-101-253
CAS No:186901-48-4
Synonyms/Alias:cortistatin14;Cortistatin 14;cortistatin;193829-96-8;Cortistatin 14, human, rat;Cortistatin-14;186901-48-4;Cortistatin-14 (trifluoroacetate salt);CST-14;Corticostatin-14;CHEMBL5192321;BDBM85324;DTXSID00583202;PUBCHEM_16133803;HY-P1212;Cortistatin-14, >=97% (HPLC);AKOS024457590;NCGC00167271-01;DA-52063;DA-52064;CAS_186901-48-4;CS-0029008;
Cortistatin 14 (mouse, rat) is a synthetic peptide corresponding to the biologically active 14-amino acid form of cortistatin found in murine species. As a neuropeptide structurally related to somatostatin, cortistatin exhibits unique receptor affinities and physiological roles, particularly within the central nervous system. Its sequence and functional motifs enable it to interact with both somatostatin and cortistatin receptors, contributing to the modulation of neuronal activity, neuroendocrine signaling, and immune responses. The availability of this peptide in research-grade form allows for precise experimental manipulation and detailed study of its molecular and physiological functions in rodent models.
Neuroscience research: Cortistatin 14 is widely employed in neuroscience to elucidate its role in regulating neuronal excitability and synaptic transmission. By acting on specific G protein-coupled receptors, it can modulate the activity of various neuronal populations, providing insight into mechanisms underlying sleep regulation, neuronal oscillations, and inhibitory neurotransmission. Researchers utilize this peptide to dissect the neurochemical pathways that distinguish cortistatin from somatostatin, thereby advancing understanding of peptidergic modulation in the brain.
Neuroendocrine signaling studies: The peptide is instrumental in exploring the regulatory effects on hormone secretion within the hypothalamic-pituitary axis. Its ability to bind to multiple somatostatin receptor subtypes, as well as its own distinct receptors, enables detailed investigation of feedback mechanisms controlling the release of growth hormone, adrenocorticotropic hormone, and other pituitary-derived factors. Such studies are essential for delineating the complex interplay between neuropeptides and endocrine function in rodent models.
Immunomodulation assays: Cortistatin 14 is increasingly recognized for its capacity to influence immune cell activity, particularly in the context of inflammation and cytokine production. Investigators employ the peptide in vitro and in vivo to characterize its effects on macrophages, T lymphocytes, and other immune cell populations. These applications help clarify the molecular mechanisms by which cortistatin modulates immune responses, offering valuable data for fundamental immunology and neuroimmunology research.
Peptide receptor pharmacology: The availability of cortistatin 14 enables detailed pharmacological profiling of both native and recombinant cortistatin and somatostatin receptors. By serving as a selective ligand, it facilitates binding studies, signal transduction assays, and receptor subtype discrimination. Such research is crucial for mapping receptor distribution, understanding ligand-receptor specificity, and developing new tools for receptor-targeted investigations in rodent systems.
Peptide synthesis and analytical validation: As a well-characterized neuropeptide, cortistatin 14 serves as a reference standard and positive control in peptide synthesis, purification, and analytical method development. Laboratories utilize the peptide to optimize chromatographic separation, mass spectrometric detection, and quality assessment protocols, ensuring the reliability and reproducibility of experimental workflows involving neuropeptides and related biomolecules. Its defined sequence and physicochemical properties make it a valuable benchmark for method validation and peptide-based assay calibration.
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