Cortistatin 14 (mouse, rat)

Cortistatin-14 expressed in the cortex and hippocampus. Structural and functional similarities to somatostatin-14. Neuronal depressant and sleep-modulating properties in vivo. An important mediator of immunity and inflammation.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Cortistatin 14 (mouse, rat)(CAS 186901-48-4)

CAT No: 10-101-253

CAS No:186901-48-4

Synonyms/Alias:cortistatin14;Cortistatin 14;cortistatin;193829-96-8;Cortistatin 14, human, rat;Cortistatin-14;186901-48-4;Cortistatin-14 (trifluoroacetate salt);CST-14;Corticostatin-14;CHEMBL5192321;BDBM85324;DTXSID00583202;PUBCHEM_16133803;HY-P1212;Cortistatin-14, >=97% (HPLC);AKOS024457590;NCGC00167271-01;DA-52063;DA-52064;CAS_186901-48-4;CS-0029008;

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M.F/Formula
C81H113N19O19S2
M.W/Mr.
1721
Sequence
One Letter Code:PCKNFFWKTFSSCK
Three Letter Code:H-Pro-Cys(1)-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys(1)-Lys-OH
Application
Cortistatin-14 may be used in competition binding assay with sst4 receptors (CHO-sst4) of CHO cells and sst1 receptors (CHO-sst1).[5]
Appearance
White or off-white lyophilized powder
Purity
≥97% (HPLC)
Source#
Synthetic
Long-term Storage Conditions
1% acetic acid: 1 mg/mL
InChI
InChI=1S/C81H113N19O19S2/c1-46(103)67-80(117)95-59(38-49-24-9-4-10-25-49)73(110)96-62(42-101)76(113)97-63(43-102)77(114)99-65(79(116)90-56(81(118)119)30-15-18-34-84)45-121-120-44-64(98-68(105)53-31-19-35-86-53)78(115)89-54(28-13-16-32-82)69(106)94-61(40-66(85)104)75(112)92-57(36-47-20-5-2-6-21-47)71(108)91-58(37-48-22-7-3-8-23-48)72(109)93-60(39-50-41-87-52-27-12-11-26-51(50)52)74(111)88-55(70(107)100-67)29-14-17-33-83/h2-12,20-27,41,46,53-65,67,86-87,101-103H,13-19,28-40,42-45,82-84H2,1H3,(H2,85,104)(H,88,111)(H,89,115)(H,90,116)(H,91,108)(H,92,112)(H,93,109)(H,94,106)(H,95,117)(H,96,110)(H,97,113)(H,98,105)(H,99,114)(H,100,107)(H,118,119)/t46-,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,67+/m1/s1
InChI Key
DDRPLNQJNRBRNY-WYYADCIBSA-N
Canonical SMILES
CC(C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)CC5=CC=CC=C5)CC(=O)N)CCCCN)NC(=O)C6CCCN6)C(=O)NC(CCCCN)C(=O)O)CO)CO)CC7=CC=CC=C7)O

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