Cortistatin-8 features a compact peptide containing diverse residues that shape folding, binding, and conformational transitions. Aromatic and charged motifs promote structured interaction patterns. Researchers explore its stability and receptor-associated behavior. Uses include motif characterization, structural modeling, and peptide engineering.
CAT No: R2484
CAS No:485803-62-1
Synonyms/Alias:CORTISTATIN-8;(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-16-benzyl-N-[(2S)-1,6-diamino-1-oxohexan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-[[(2S)-pyrrolidine-2-carbonyl]amino]-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide;485803-62-1;HY-P1139;AKOS024457392;PD079538;CS-0028064;(4R,7S,10S,13R,16S,19R)-13-((1H-indol-3-yl)methyl)-10-(4-aminobutyl)-16-benzyl-N-((S)-1,6-diamino-1-oxohexan-2-yl)-7-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-19-((S)-pyrrolidine-2-carboxamido)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxam;
Cortistatin-8 is a synthetic peptide analog derived from the cortistatin neuropeptide family, characterized by its structural similarity to somatostatin and its unique biological activities within the central nervous system and peripheral tissues. As a member of the cortistatin peptide group, it is distinguished by its ability to interact with somatostatin receptors and modulate a range of physiological processes, including neurotransmission, hormone secretion, and immune regulation. Research into cortistatin analogs such as Cortistatin-8 has expanded significantly in recent years, owing to their potential for dissecting neuropeptide signaling pathways and elucidating receptor-ligand interactions that are not fully addressed by somatostatin alone. The compound's stability and receptor selectivity make it a valuable tool for both fundamental and applied studies in neuroendocrinology and immunology.
Receptor Pharmacology: Cortistatin-8 is extensively utilized in receptor binding assays and pharmacological profiling to investigate its affinity and selectivity for various somatostatin receptor subtypes (SSTRs). By serving as a ligand in competitive binding studies, it enables researchers to delineate the specific receptor interactions that differentiate cortistatin from somatostatin, thereby advancing understanding of neuropeptide-receptor dynamics in both neuronal and peripheral tissues. Such studies are critical for mapping receptor signaling cascades and exploring the molecular basis of peptide-receptor specificity.
Neurophysiological Research: The peptide is applied in electrophysiological and neurochemical experiments aimed at exploring its modulatory effects on neuronal excitability and synaptic transmission. Its unique capacity to influence cortical oscillatory activity and neuronal firing patterns allows investigators to probe the physiological roles of endogenously expressed cortistatin in brain circuits. Use of Cortistatin-8 in these contexts provides insight into mechanisms underlying sleep regulation, cortical synchronization, and the modulation of neurotransmitter release.
Peptide Structure-Activity Relationship Studies: In the field of peptide chemistry, Cortistatin-8 serves as a model compound for structure-activity relationship (SAR) investigations. By systematically modifying its amino acid sequence or backbone, researchers can assess the impact of specific residues on biological activity, receptor affinity, and metabolic stability. These SAR studies are instrumental for designing novel peptide analogs with tailored pharmacological profiles, contributing to the broader understanding of peptide engineering and functional optimization.
Immunomodulation Assays: Experimental protocols in immunology employ Cortistatin-8 to investigate its effects on immune cell signaling and cytokine production. Its interaction with immune receptors and influence on inflammatory mediators provide a platform for dissecting the role of neuropeptides in immune regulation. The compound's application in in vitro and ex vivo assays supports research into neuroimmune communication, offering a pathway to unravel the complex interactions between the nervous and immune systems.
Peptide-Based Drug Discovery: As a stable and selective cortistatin analog, Cortistatin-8 is integrated into early-stage drug discovery workflows focused on neuropeptide-based therapeutic targets. Its use in high-throughput screening, lead optimization, and mechanistic studies enables the identification of novel modulators of somatostatin and cortistatin receptors. By facilitating the evaluation of efficacy, selectivity, and metabolic properties in peptide libraries, it contributes to the rational design of next-generation peptide therapeutics and research probes.
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