Cotadutide is a dual receptor agonist that modifies the activity of glucagon and glucagon-like peptide-1 (GLP-1).
CAT No: R1942
CAS No:1686108-82-6
Synonyms/Alias:Cotadutide; MEDI0382; MEDI 0382; MEDI-0382
Chemical Name:(2S)-5-[[(5S)-5-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-6-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-carbamimidamido-1-[[(2S)-1-[[(2S)-5-carbamimidamido-1-[[(2S)-3-carboxy-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-carboxy-1-[[(2S)-1-[[2-(carboxymethylamino)-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-6-oxohexyl]amino]-2-(hexadecanoylamino)-5-oxopentanoic acid
Cotadutide is a synthetic peptide compound designed as a dual agonist targeting both the glucagon-like peptide-1 (GLP-1) receptor and the glucagon receptor. Structurally, it combines peptide sequences that enable selective receptor engagement, resulting in multifaceted metabolic modulation. Due to its unique dual-agonist mechanism, cotadutide has emerged as a valuable tool in the study of metabolic pathways, especially those involving glucose homeostasis and energy balance. Researchers utilize this compound to dissect complex peptide-receptor interactions and to model physiological responses relevant to metabolic regulation. Its biochemical profile and receptor specificity make it a prominent subject in advanced peptide research and metabolic signaling studies.
Metabolic pathway research: Cotadutide is widely employed in laboratory settings to investigate the interplay between GLP-1 and glucagon receptor signaling. By activating both receptors, it enables detailed analyses of downstream signaling cascades that regulate glucose metabolism, hepatic glucose output, and insulin secretion. Researchers use it to map crosstalk between peptide hormone pathways and to elucidate the regulatory mechanisms that underpin energy homeostasis. This dual-agonist peptide provides a sophisticated tool for probing the balance between anabolic and catabolic processes within metabolic tissues.
Peptide receptor pharmacology: As a bifunctional peptide agonist, cotadutide serves as a model compound in receptor pharmacology studies. It allows scientists to assess receptor binding affinities, activation kinetics, and signal transduction profiles under controlled experimental conditions. Such studies are essential for understanding the structure-activity relationships that govern peptide-receptor interactions, as well as for characterizing the selectivity and efficacy of novel peptide ligands. The compound's dual activity facilitates comparative analyses of receptor-specific and combined signaling outcomes.
In vitro functional assays: Cotadutide is frequently utilized in cell-based assays to evaluate its effects on metabolic endpoints such as cAMP production, glucose uptake, and lipid metabolism. These in vitro experiments are instrumental for dissecting the cellular consequences of dual GLP-1 and glucagon receptor activation. By employing this peptide in diverse cell lines, researchers can monitor receptor-specific responses, quantify downstream effector activation, and explore the modulation of gene expression linked to metabolic control.
Peptide synthesis and analog development: The molecular architecture of cotadutide provides a template for synthetic peptide chemistry and analog design. Its structure is studied to optimize peptide stability, receptor selectivity, and pharmacodynamic properties. Chemists and biochemists leverage this knowledge to develop new dual-agonist peptides or to modify existing sequences for improved research utility. The compound's sequence and functional motifs inform the rational design of next-generation peptide ligands tailored for specific experimental objectives.
Animal model studies: In preclinical research, cotadutide is applied in animal models to investigate its impact on whole-body metabolism and energy expenditure. Through controlled administration, scientists can assess changes in glucose tolerance, hepatic function, and adipose tissue dynamics. Such studies provide valuable insights into the physiological roles of GLP-1 and glucagon signaling in vivo, supporting the development of mechanistic models of metabolic regulation. The use of this dual-agonist peptide in animal systems enables comprehensive evaluation of its biological activity and metabolic consequences under physiologically relevant conditions.
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