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CTOP

CTOP is a peptide that acts as a μ-opioid receptor antagonist.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
CTOP(CAS 103429-31-8)

CAT No: R1808

CAS No:103429-31-8

Synonyms/Alias:CTOP;CTOPA;103429-31-8;Ctop-NH2;Cys(2)-tyr(3)-orn(5)-pen(7)-amide;Phe-cycl(cys-tyr-trp-orn-thr-pen)thr-NH2;N-(1-amino-3-hydroxy-1-oxobutan-2-yl)-19-[(2-amino-3-phenylpropanoyl)amino]-10-(3-aminopropyl)-7-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-3,3-dimethyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide;Phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide;L-Threoninamide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-ornithyl-L-threonyl-3-mercapto-L-valyl-, cyclic (2-7)-disulfide;FCYWXTXT;CTOP TFA;CTOP?;SCHEMBL1239661;CHEBI:230371;PZWWYAHWHHNCHO-UHFFFAOYSA-N;AS-85089;FP108621;C20160;L000207;H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Disulfide bond between Cys2 and Pen7);

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C50H67N11O11S2
M.W/Mr.
1062.3
Sequence
One Letter Code:FCYWXXXX
Three Letter Code:H-DL-Phe-DL-Cys(1)-DL-Tyr-DL-Trp-DL-Orn-DL-xiThr-DL-Pen(1)-DL-xiThr-NH2
Biological Activity
Potent and selective μ opioid receptor antagonist (Ki values are 0.96 and >10,000 nM for μ and δ receptors respectively). Causes behavioral effects on central administration in vivo. Also increases K+ currents in rat locus ceruleus neurons in vitro via a μ receptor independent mechanism.
Long-term Storage Conditions
Soluble to 1 mg/ml in water
Shipping Condition
Room temperature in continental US; may vary elsewhere.
InChI
InChI=1S/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23-30-24-54-34-14-9-8-13-32(30)34)46(69)55-35(15-10-20-51)44(67)60-40(27(2)63)48(71)61-41/h5-9,11-14,16-19,24,26-27,33,35-41,54,62-64H,10,15,20-23,25,51-52H2,1-4H3,(H2,53,65)(H,55,69)(H,56,70)(H,57,68)(H,58,66)(H,59,72)(H,60,67)(H,61,71)
InChI Key
PZWWYAHWHHNCHO-UHFFFAOYSA-N

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