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(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin

CAT#

R1081

CAS No.

73168-24-8

Description

Selective antagonist of vasopressin V1A receptor that inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and induces anxiolytic-like effects in the dorsal, but not ventral, hippocampus in vivo.

Synonyms/Alias

Manning Compound, [Pmp1, Tyr(OMe)2, Arg8] Vasopressin; β-Mercapto-β,β-cyclopentamethylene-propionyl-Tyr(Me)-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 trifluoroacetate salt (Disulfide bond)

Molecular Formula

C52H74N14O12S2

M.W/Mr.

1151.38

Sequence

YFQNCPRG(Modifications: Tyr-1 = Pmp-Tyr(Me), Gly-8 = C-terminal amide)

Labeling Target

Vasopressin Receptor

Appearance

White lyophilised solid

Purity

>98%

Activity

Antagonist

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(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin

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