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Difelikefalin acetate

Difelikefalin ,also known as D-Phe-D-Phe-D-Leu-D-Lys-[γ-(4-N-piperidinyl)amino carboxylic acid] (as the acetate salt), is an analgesic opioid peptide acting as a peripherally specific, highly selective agonist of the κ-opioid receptor (KOR).

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: 10-101-174

CAS No:1024828-77-0(net);1024829-44-4

Synonyms/Alias:Difelikefalin acetate;CR845 acetate;CR-845 acetate;1024829-44-4;UNII-0P70AR5BYB;0P70AR5BYB;Korsuva;4-Amino-1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysl)-piperidine-4-carboxylic acid, acetate salt;acetic acid;4-amino-1-[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid;CHEMBL5315123;1024828-77-0 , Difelikefalin;DIFELIKEFALIN ACETATE [WHO-DD];TS-10624;DIFELIKEFALIN ACETATE [ORANGE BOOK];4-Amino-1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)piperidine-4-carboxylic acid acetate;N1-(D-Phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-amino-4-piperidinecarboxylic acid acetate (1:);N1-(D-Phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-amino-4-piperidinecarboxylic acid acetate (1:?);

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cGMP Peptide
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M.F/Formula
C38H57N7O8
M.W/Mr.
739.9
Labeling Target
K-opioid receptor
Application
Difelikefalin is an intravenous agent for the treatment of postoperative pain.
Activity
Agonist
Biological Activity
Difelikefalin acetate is a kappa opiate receptor agonist that is used for its antipruritic effects.
Areas of Interest
Postoperative pain
Source#
Synthetic
InChI
InChI=1S/C36H53N7O6.C2H4O2/c1-24(2)21-29(32(45)40-28(15-9-10-18-37)34(47)43-19-16-36(39,17-20-43)35(48)49)42-33(46)30(23-26-13-7-4-8-14-26)41-31(44)27(38)22-25-11-5-3-6-12-25;1-2(3)4/h3-8,11-14,24,27-30H,9-10,15-23,37-39H2,1-2H3,(H,40,45)(H,41,44)(H,42,46)(H,48,49);1H3,(H,3,4)/t27-,28-,29-,30-;/m1./s1
InChI Key
MZWHRPKAHCWTOI-KGURMGBCSA-N
Isomeric SMILES
CC(C)C[C@H](C(=O)N[C@H](CCCCN)C(=O)N1CCC(CC1)(C(=O)O)N)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC3=CC=CC=C3)N.CC(=O)O

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