Difelikefalin acetate

Difelikefalin ,also known as D-Phe-D-Phe-D-Leu-D-Lys-[γ-(4-N-piperidinyl)amino carboxylic acid] (as the acetate salt), is an analgesic opioid peptide acting as a peripherally specific, highly selective agonist of the κ-opioid receptor (KOR).

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CAT#	10-101-174
CAS	1024828-77-0(net);1024829-44-4
Synonyms/Alias	CR845 acetate;CR-845 acetate;UNII-0P70AR5BYB; 0P70AR5BYB;
M.F/Formula	C38H57N7O8
M.W/Mr.	739.90128
Labeling Target	K-opioid receptor
Application	Difelikefalin is an intravenous agent for the treatment of postoperative pain.
Activity	Agonist
Biological Activity	Difelikefalin acetate is a kappa opiate receptor agonist that is used for its antipruritic effects.
Areas of Interest	Postoperative pain
Disease	Acute Pain and Postoperative Pain

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Source#	Synthetic
Storage	-20°C
InChI	InChI=1S/C36H53N7O6.C2H4O2/c1-24(2)21-29(32(45)40-28(15-9-10-18-37)34(47)43-19-16-36(39,17-20-43)35(48)49)42-33(46)30(23-26-13-7-4-8-14-26)41-31(44)27(38)22-25-11-5-3-6-12-25;1-2(3)4/h3-8,11-14,24,27-30H,9-10,15-23,37-39H2,1-2H3,(H,40,45)(H,41,44)(H,42,46)(H,48,49);1H3,(H,3,4)/t27-,28-,29-,30-;/m1./s1
InChI Key	MZWHRPKAHCWTOI-KGURMGBCSA-N
Isomeric SMILES	CC(C)C[C@H](C(=O)N[C@H](CCCCN)C(=O)N1CCC(CC1)(C(=O)O)N)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC3=CC=CC=C3)N.CC(=O)O