Difelikefalin is a novel and potent kappa-opioid receptor agonist, exhibits low P450 CYP inhibition and low penetration into the brain. Difelikefalin may be useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions.
CAT No: R1893
CAS No:1024828-77-0
Synonyms/Alias:Difelikefalin;1024828-77-0;CR845;CR-845;MR13A9;Difelikefalin [INN];difelicefalina;difelikefaline;Difelikefalin (CR845);FE202845;UNII-NA1U919MRO;NA1U919MRO;FE-202845;MR-13A9;CR 845;SEQ ID NO: 2;1024828-77-0 (free base);4-amino-1-[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid;4-Piperidinecarboxylic acid, N1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-amino-;4-Piperidinecarboxylic acid, 4-amino-1-((2R)-6-amino-2-(((2R)-2-(((2R)-2-(((2R)-2-amino-1-oxo-3-phenylpropyl)amino)-1-oxo-3-phenylpropyl)amino)-4-methyl-1-oxopentyl)amino)-1-oxohexyl)-;1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-aminopiperidine-4-carboxylic acid;4-AMINO-1-(D-PHENYLALANYL-D-PHENYLALANYL-D-LEUCYL-D-LYSYL)PIPERIDINE-4-CARBOXYLIC ACID;4-Piperidinecarboylic acid, 4-amino-1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-;N-((2R)-1-(((2R)-1-(((2R)-6-Amino-1-(4-amino-4-carboxy-1-piperidinyl)-1-oxo-2-hexanyl)amino)-4-methyl-1-oxo-2-pentanyl)amino)-1-oxo-3-phenyl-2-propanyl)-D-phenylalaninamide;difelikefalinum;Kapruvia;D-Phe-D-Phe-D-Leu-D-Lys-(gamma-(4-N-piperidinyl)amino carboxylic acid);D-Phe-D-Phe-D-Leu-D-Lys-[gamma-(4-N-piperidinyl)amino carboxylic acid];Difelikefalin TFA;Difelikefalin (USAN/INN);Difelikefalin [USAN:INN];DIFELIKEFALIN [USAN];DIFELIKEFALIN [WHO-DD];GTPL9044;CHEMBL3989915;SCHEMBL10316464;BDBM235785;DTXSID401032896;DIFELIKEFALIN ACETATE [JAN];BCP24752;EX-A5855;AKOS040756421;AT30197;DB11938;BD177570;DA-52529;HY-17609;MS-31091;CR-845; FE-202845;CS-0014687;NS00072889;D11111;US9359399, 2;EN300-7445060;Q21098992;4-amino-1-[(2R)-6-amino-2-[(2R)-2-[(2R)-2-[(2R)-2-amino-3-phenylpropanamido]-3-phenylpropanamido]-4-methylpentanamido]hexanoyl]piperidine-4-carboxylic acid;Difelikefalin; 4-Piperidinecarboxylic acid, N1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-amino-; N1-(D-Phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-amino-4-piperidinecarboxylic acid; CR 845; Difelikefalin;
Chemical Name:4-amino-1-[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid
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