Dihydrosomatostatin incorporates a reduced peptide backbone that influences conformational rigidity and stability. Residue diversity supports investigations of binding dynamics, folding behavior, and solvent interactions. Researchers examine its structural transitions to understand hydrogen-bond networks. Use spans peptide analog design, structural modeling, and signaling-pathway exploration.
CAT No: R2646
CAS No:40958-31-4
Synonyms/Alias:Dihydrosomatostatin;Somatostatin-14 (reduced);40958-31-4;Somatostatin (15-28);Somatostatin (sheep reduced);DTXSID00193961;SCHEMBL11592550;SCHEMBL25286356;Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys;DTXCID40116452;HY-P4917;DA-67693;FS109331;CS-0674980;NS00126763;H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH;H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH; H-AGCKNFFWKTFTSC-OH;Somatostatin-14 (reduced) (H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH);
Dihydrosomatostatin, also known as reduced somatostatin, is a synthetic analog of the naturally occurring peptide hormone somatostatin. Featuring a fully hydrogenated disulfide bridge, this carbohydrate compound exhibits enhanced stability against enzymatic degradation, which makes it a valuable tool in biochemical research. Dihydrosomatostatin retains the core structural motifs necessary for receptor binding, allowing it to modulate the activity of somatostatin receptors with high specificity. Its unique chemical properties have enabled researchers to explore new avenues in cell signaling, hormone regulation, and receptor-ligand interactions, broadening the understanding of somatostatin's physiological roles. The compound's resistance to rapid metabolic breakdown further extends its functional lifespan in experimental systems, providing more reliable and reproducible results in laboratory studies.
Neuroendocrine Signaling Research: Dihydrosomatostatin serves as an essential probe in neuroendocrine signaling investigations. By mimicking the inhibitory action of endogenous somatostatin on hormone secretion, it allows researchers to dissect the regulatory mechanisms governing the release of growth hormone, insulin, and glucagon. Its enhanced stability compared to native somatostatin makes it particularly suitable for in vitro and ex vivo experiments where prolonged receptor engagement is necessary. Through the use of this analog, scientists can gain deeper insights into feedback loops and signal transduction pathways that control endocrine function, contributing to a better understanding of metabolic and neuroendocrine disorders.
Receptor Binding Studies: The compound is widely utilized in receptor binding assays to characterize the interaction between somatostatin analogs and their receptors. Its resistance to enzymatic degradation ensures that binding kinetics and affinity measurements remain accurate over extended periods. Researchers employ dihydrosomatostatin in competitive binding experiments to map receptor subtypes, analyze ligand specificity, and investigate the structural requirements for high-affinity receptor engagement. These studies are crucial for elucidating the molecular determinants of receptor-ligand interactions and for the rational design of novel receptor modulators.
Peptide Stability Assessments: Reduced somatostatin is frequently used as a model system to evaluate peptide stability under various physiological and experimental conditions. Its robust resistance to proteolytic enzymes provides a benchmark for comparing the degradation profiles of other peptide-based compounds. By studying its stability, researchers can optimize formulation strategies, develop protective delivery systems, and engineer new analogs with improved pharmacokinetic properties for research applications. This knowledge is instrumental in advancing the field of peptide therapeutics and in the development of experimental tools for life sciences research.
Signal Transduction Investigations: The ability of dihydrosomatostatin to selectively activate somatostatin receptors makes it a powerful tool for dissecting downstream signaling events. Scientists employ this analog to stimulate or inhibit specific signaling cascades, such as the inhibition of adenylate cyclase activity or the modulation of ion channel conductance. These experiments help clarify the role of somatostatin receptors in cellular communication, synaptic plasticity, and neuroprotection. By manipulating signaling pathways with this stable analog, researchers can identify new molecular targets and unravel the complex networks that regulate cellular responses to external stimuli.
Immunological Studies: In immunological research, dihydrosomatostatin is utilized to probe the immunomodulatory effects of somatostatin analogs on immune cell function. Its stability permits extended incubation periods in cell culture, enabling detailed analysis of cytokine secretion, lymphocyte proliferation, and macrophage activity. These studies provide valuable information on the interplay between the neuroendocrine and immune systems, revealing how somatostatin signaling influences immune responses and inflammation. The insights gained from such research contribute to a broader understanding of immune regulation and the potential for targeting somatostatin pathways in immunological disorders.
In summary, dihydrosomatostatin stands out as a versatile and robust research tool with applications spanning neuroendocrine signaling, receptor binding studies, peptide stability assessments, signal transduction investigations, and immunological studies. Its unique chemical properties and enhanced stability make it indispensable for advancing scientific knowledge in multiple fields, supporting the development of new experimental models, and facilitating the discovery of innovative therapeutic strategies in basic and applied research contexts.
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