Dolcanatide, a therapeutic peptide, assumes a pivotal role within the biomedical sector for confronting intricate gastrointestinal disorders, notably inflammatory bowel disease (IBD) encompassing Crohn's disease and ulcerative colitis. By precisely engaging specific receptors within the gut, Dolcanatide adeptly alleviates inflammation, subsequently mitigating the distressing symptoms that accompany IBD. Its anti-inflammatory properties demonstrate profound potential in ameliorating the intricate pathogenesis of these debilitating ailments.
CAT No: R2075
CAS No:1092457-65-2
Synonyms/Alias:Dolcanatide;Dolcanatide [USAN];UNII-WU977T914K;1092457-65-2;SP-333;WU977T914K;D-Leucine, D-asparaginyl-L-alpha-aspartyl-L-alpha-glutamyl-L-cysteinyl-L-alpha-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4->12),(7->15)-bis(disulfide);dolcanatidum;DOLCANATIDE [INN];Dolcanatide (SP-333);DOLCANATIDE [WHO-DD];CHEMBL5174775;GTPL10011;SP333;HY-P3499;SP 333;DA-52656;CS-0615000;431-220-9;asn-asp-glu-cys-glu-leu-cys-val-asn-val-ala-cys-thr-gly-cys-leu (4->12),(7->15)-bis(disulfide);D-ASN-ASP-GLU-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-D-LEU (4->12),(7->15)-BIS(DISULFIDE);D-LEUCINE, D-ASPARAGINYL-L-.ALPHA.-ASPARTYL-L-.ALPHA.-GLUTAMYL-L-CYSTEINYL-L-.ALPHA.-GLUTAMYL-L-LEUCYL-L-CYSTEINYL-L-VALYL-L-ASPARAGINYL-L-VALYL-L-ALANYL-L-CYSTEINYL-L-THREONYLGLYCYL-L-CYSTEINYL-, CYCLIC (4->12),(7->15)-BIS(DISULFIDE);D-Leucine, D-asparaginyl-L-alpha-aspartyl-L-alpha-glutamyl-L-cysteinyl-L-alpha-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4-->12),(7-->15)-bis(disulfide);
Chemical Name:(2R)-2-[[(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(2-amino-2-oxoethyl)-25-[[(2S)-4-carboxy-2-[[(2S)-3-carboxy-2-[[(2R)-2,4-diamino-4-oxobutanoyl]amino]propanoyl]amino]butanoyl]amino]-22-(2-carboxyethyl)-32-[(1R)-1-hydroxyethyl]-4-methyl-19-(2-methylpropyl)-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-7,13-di(propan-2-yl)-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecazabicyclo[14.13.13]dotetracontane-38-carbonyl]amino]-4-methylpentanoic acid
Dolcanatide is a synthetic peptide analog designed to mimic the activity of endogenous uroguanylin, a member of the guanylin peptide family. Structurally characterized by its stability and selective agonism of guanylate cyclase-C (GC-C) receptors, Dolcanatide has garnered significant interest in gastrointestinal research and peptide pharmacology. Its resistance to proteolytic degradation and its ability to modulate cyclic GMP (cGMP) signaling pathways render it a valuable biochemical tool for investigating mechanisms of intestinal fluid homeostasis, epithelial function, and peptide-receptor interactions. As a research-use-only compound, Dolcanatide is well-suited for advanced studies in peptide biology and related biomedical fields.
Peptide signaling research: Dolcanatide serves as a robust model compound for dissecting the molecular dynamics of GC-C receptor activation. Through its high affinity and selectivity for this receptor, the peptide enables researchers to explore downstream signaling events, such as cGMP production and protein kinase activation, in both in vitro and ex vivo systems. Studies utilizing Dolcanatide provide critical insights into how peptide ligands regulate ion transport, fluid secretion, and electrolyte balance within the gastrointestinal epithelium.
Epithelial physiology studies: In experimental models, Dolcanatide is frequently employed to probe the regulatory mechanisms underlying epithelial barrier function and mucosal integrity. By modulating cGMP-dependent pathways, it allows for precise assessment of how peptide agonists influence tight junction dynamics, paracellular permeability, and cellular responses to inflammatory stimuli. Such investigations support a deeper understanding of epithelial homeostasis and the pathophysiology of barrier dysfunction.
Peptide-receptor interaction assays: As a chemically stable and biologically active peptide, Dolcanatide is an excellent probe for receptor binding studies, ligand-receptor affinity measurements, and structure-activity relationship (SAR) analyses. Its use in competitive binding assays and biophysical characterization helps elucidate the determinants of GC-C receptor specificity and the conformational requirements for agonist activity. These data are instrumental in guiding the rational design of next-generation peptide analogs for research applications.
Intestinal transport and absorption models: The compound is widely utilized in simulated gastrointestinal systems and cell-based transport assays to investigate the kinetics of peptide absorption, trans-epithelial migration, and the role of GC-C signaling in nutrient and fluid movement. By incorporating Dolcanatide into these experimental frameworks, researchers can quantitatively assess the impact of guanylin analogs on intestinal physiology and the modulation of transporter proteins.
Peptide stability and degradation studies: Due to its engineered resistance to proteolytic enzymes, Dolcanatide is a preferred substrate in studies evaluating peptide stability in biological matrices. Researchers leverage its unique properties to benchmark enzymatic degradation rates, characterize metabolic pathways, and optimize formulation strategies for peptide-based research reagents. Such studies contribute valuable data to the broader field of peptide chemistry and the development of stable bioactive peptides for laboratory use.
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