Endotoxin inhibitor is a synthetic ligand featuring hydrophobic and charged functionalities that modulate biomolecular recognition. Researchers employ it to examine noncovalent interaction networks, conformational stability, and solvent-driven orientation. Its structure supports detailed mechanistic modeling. The compound's versatility aids biochemical investigation.
CAT No: R2304
CAS No:147396-10-9
Synonyms/Alias:Endotoxin inhibitor;147396-10-9;(4R,7S,10S,13S,16S,19S,22R)-7,10,19-tris(4-aminobutyl)-22-[[(2S)-6-amino-2-[[(2S,3R)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-16-benzyl-13-(2-methylpropyl)-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexazacyclotricosane-4-carboxylic acid;MFCD00214319;HY-P3912;DA-52899;FE108431;PD159225;CS-0627813;H-Lys-Thr-Lys-Cys-Lys-Phe-Leu-Lys-Lys-Cys-OH; H-KTKCKFLKKC-OH;
Endotoxin inhibitor is a specialized compound designed to neutralize or block the biological activity of endotoxins, which are lipopolysaccharide components found in the outer membrane of Gram-negative bacteria. Engineered for use in research and development environments, this inhibitor offers a reliable tool for scientists investigating the molecular mechanisms underlying endotoxin-mediated responses. Its unique mode of action allows for precise modulation of endotoxin activity, making it invaluable in studies focused on cellular signaling, inflammation, and immune response. By selectively targeting the interaction between endotoxins and their corresponding receptors, the compound provides an efficient means to dissect complex biological pathways without interfering with other cellular processes.
Immunology research: In immunological studies, the endotoxin inhibitor is frequently utilized to explore the role of bacterial endotoxins in immune system activation. By incorporating the inhibitor into cell culture experiments, researchers can effectively suppress endotoxin-induced cytokine production, thereby clarifying the contributions of specific signaling molecules. This approach is instrumental in distinguishing between direct pathogen effects and those mediated through endotoxin-triggered pathways, enhancing the accuracy of immune response analyses.
Inflammation modeling: Within inflammation research, the compound serves as a critical tool for delineating the molecular events that drive inflammatory cascades. Scientists employ the inhibitor to block endotoxin-induced activation of pro-inflammatory transcription factors, such as NF-κB, allowing for a detailed examination of downstream gene expression. This targeted inhibition facilitates the development of experimental models that accurately reflect the interplay between pathogens and host tissues, paving the way for new insights into the regulation of inflammation.
Cellular signaling studies: Endotoxin inhibitors are widely used in cell biology to investigate the signaling pathways activated by endotoxins. By selectively preventing the engagement of endotoxins with pattern recognition receptors like TLR4, the inhibitor helps researchers map the sequence of intracellular events following exposure to bacterial components. This enables the identification of novel signaling intermediates and regulatory checkpoints, contributing to a deeper understanding of cellular responses to microbial challenge.
Bioprocessing and biomanufacturing: In the field of bioprocessing, the compound is applied to mitigate the effects of endotoxin contamination in cell-based production systems. By incorporating the inhibitor during upstream or downstream processing, manufacturers can minimize the impact of endotoxins on cell viability and productivity. This improves the reliability of experimental outcomes and supports the generation of high-quality biological products for further research and development applications.
Diagnostic assay development: The use of endotoxin inhibitors extends to the optimization of diagnostic assays, where they are employed to eliminate confounding effects caused by trace endotoxin contamination. By adding the inhibitor to assay reagents or sample preparations, developers can ensure that observed biological responses are attributable to the analyte of interest rather than unintended endotoxin activity. This enhances the specificity and sensitivity of immunoassays, cell-based assays, and other analytical platforms, contributing to the advancement of robust diagnostic tools for a variety of research settings.
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