Epithalon is a synthetic tetra-peptide used to regulate the cell cycle through up-regulation of telomerase activity showing anticancer and anti-tumor metastatic effect.
CAT No: 10-101-217
CAS No:307297-39-8
Synonyms/Alias:Epitalon;307297-39-8;Epithalon;Glycine, L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-;Ala-Glu-Asp-Gly;(4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid;64082-79-7;O65P17785G;Epithalamin;Epithalamine;Epithalon?;UNII-O65P17785G;AE-0 peptide;Glycine, L-alanyl-L-a-glutamyl-L-a-aspartyl-;alanyl-glutamyl-aspartyl-glycine;SCHEMBL5685928;DTXSID80952957;CHEBI:230091;GLXC-25920;BCP13981;HMA29739;HY-P1149;(S)-4-((S)-2-aminopropanamido)-5-(((S)-3-carboxy-1-((carboxymethyl)amino)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid;AC-33517;DA-63233;CS-0028299;G63737;Q27285389;GLYCINE, L-ALANYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-ASPARTYL-;
Epithalone is a synthetic tetrapeptide that has garnered significant attention within the field of peptide biochemistry due to its unique sequence and functional properties. Structurally composed of the amino acids alanine, glutamic acid, aspartic acid, and glycine, it serves as a model compound for studying the regulatory roles of short peptides in cellular processes. Its relevance extends across molecular biology, biochemistry, and aging research, where it is utilized as a tool to interrogate peptide-mediated signaling pathways and the molecular mechanisms underlying cellular regulation. As a research-use peptide, Epithalone offers valuable opportunities for scientists investigating the interface between peptide structure, function, and biological activity.
Peptide signaling research: Epithalone is widely employed as a probe in studies focused on peptide-mediated signaling pathways and their impact on cellular homeostasis. Researchers utilize this tetrapeptide to examine how short peptides can modulate gene expression, protein synthesis, and cellular communication. Its defined structure makes it suitable for dissecting the molecular underpinnings of signal transduction events, particularly those associated with the regulation of cell cycle progression and stress response pathways.
Telomerase activity studies: The compound has become a prominent tool in investigations exploring the regulation of telomerase, the ribonucleoprotein enzyme responsible for maintaining telomere length in eukaryotic cells. By serving as a model substrate or modulator in in vitro assays, Epithalone enables researchers to evaluate the biochemical factors influencing telomerase activation and telomere dynamics. These studies contribute to a broader understanding of chromosomal stability, replicative senescence, and cellular longevity.
Cellular aging models: In the context of cellular senescence research, Epithalone is frequently incorporated into experimental protocols designed to simulate or modulate aging-related processes in cultured cells. Scientists leverage its properties to investigate the molecular events associated with replicative aging, oxidative stress response, and the maintenance of genomic integrity. Such applications are instrumental in elucidating the peptide's influence on age-associated biochemical pathways and cellular phenotypes.
Peptide synthesis and analog development: The structure of Epithalone provides a valuable template for peptide chemists engaged in the synthesis of novel tetrapeptide analogs. Its straightforward sequence facilitates structure-activity relationship (SAR) studies, allowing for systematic modification of individual residues to assess changes in biological activity or stability. This application supports the development of new research peptides with tailored functional attributes, expanding the toolkit available for functional genomics and proteomics studies.
Biochemical assay standardization: Due to its well-characterized sequence and stability, Epithalone is suitable for use as a reference standard or positive control in a variety of peptide-based biochemical assays. Its consistent performance in analytical techniques such as HPLC, mass spectrometry, and immunoassays enables researchers to calibrate instruments, validate assay sensitivity, and benchmark experimental results. This application ensures reproducibility and accuracy in studies involving peptide quantification or detection, supporting rigorous scientific investigation across multiple disciplines.
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