Epithalon is a synthetic tetra-peptide used to regulate the cell cycle through up-regulation of telomerase activity showing anticancer and anti-tumor metastatic effect.
CAT No: 10-101-217
CAS No:307297-39-8
Synonyms/Alias:Epitalon;307297-39-8;Epithalon;Glycine, L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-;Ala-Glu-Asp-Gly;(4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid;64082-79-7;O65P17785G;Epithalamin;Epithalamine;Epithalon?;UNII-O65P17785G;AE-0 peptide;Glycine, L-alanyl-L-a-glutamyl-L-a-aspartyl-;alanyl-glutamyl-aspartyl-glycine;SCHEMBL5685928;DTXSID80952957;CHEBI:230091;GLXC-25920;BCP13981;HMA29739;HY-P1149;(S)-4-((S)-2-aminopropanamido)-5-(((S)-3-carboxy-1-((carboxymethyl)amino)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid;AC-33517;DA-63233;CS-0028299;G63737;Q27285389;GLYCINE, L-ALANYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-ASPARTYL-;
Epithalone, also known as epitalon or epithalamin, is a synthetic tetrapeptide derived from the naturally occurring peptide epithalamin, which is secreted by the pineal gland. This compound has attracted considerable attention in the field of biochemistry and molecular biology for its potential to modulate cellular activity and promote homeostasis. Characterized by its unique amino acid sequence, epithalone is widely studied for its ability to influence telomerase activity and support genomic stability. The peptide's versatility makes it a valuable tool for researchers investigating the mechanisms of cellular aging, oxidative stress response, and epigenetic regulation. Its water solubility and compatibility with various in vitro and in vivo research models further enhance its utility across multiple scientific disciplines.
Cellular Aging Research: Epithalone serves as a key reagent in the investigation of cellular senescence and lifespan extension at the molecular level. Researchers utilize this peptide to study its effects on telomerase activation, which plays a critical role in maintaining telomere length during cell division. By enabling the exploration of telomere dynamics, epithalone provides insights into the fundamental processes underlying cellular aging and genome integrity. This application is particularly relevant for studies aiming to elucidate the molecular pathways that contribute to the aging process and to identify potential interventions that may delay cellular senescence.
Oxidative Stress Studies: Epitalon is frequently employed in research focused on cellular defense mechanisms against oxidative damage. Scientists investigate its potential to modulate antioxidant enzyme expression, reduce reactive oxygen species (ROS) production, and enhance cellular resilience to oxidative stress. Through these studies, epithalone helps clarify the molecular interactions that protect cells from environmental and metabolic insults, thereby contributing to a deeper understanding of cellular homeostasis and redox balance.
Epigenetic Regulation: The peptide is also investigated for its influence on gene expression and chromatin remodeling. By modulating epigenetic markers, such as DNA methylation and histone acetylation, epithalamin allows researchers to explore how peptide-based interventions may affect gene regulation and cellular phenotype. This application is particularly valuable in the context of developmental biology and the study of age-related changes in gene expression patterns.
Neuroendocrine Research: Epithalone's origins in the pineal gland make it a subject of interest in neuroendocrine studies. Researchers use it to examine its potential impact on melatonin synthesis and circadian rhythm regulation. By providing a model to study the interactions between peptides and neuroendocrine signaling pathways, epitalon supports investigations into sleep-wake cycles, hormonal balance, and the broader implications of pineal gland function on systemic physiology.
Tissue Regeneration and Repair: In the context of tissue engineering and regenerative biology, epithalone is explored for its ability to influence cellular proliferation and differentiation. Scientists assess its effects on stem cell activity, tissue repair mechanisms, and the maintenance of tissue-specific functions. By facilitating studies on tissue regeneration, the peptide contributes to the understanding of how peptide-based molecules can support recovery and maintenance of healthy tissue architecture.
In summary, epithalone represents a multifaceted research tool with applications spanning cellular aging, oxidative stress, epigenetic regulation, neuroendocrine function, and tissue regeneration. Its unique properties and diverse mechanisms of action make it indispensable for advancing knowledge in molecular biology, biochemistry, and physiological research. By enabling precise investigations into fundamental cellular processes, epithalamin continues to support innovative discoveries that shape our understanding of biological systems and their adaptive capacities.
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