Et-29 is a synthetic peptide analog containing alternating polar, hydrophobic, and aromatic residues that influence secondary-structure formation. Researchers employ it to explore solvent-dependent folding, β-turn stability, and ligand-recognition behavior. The motif supports investigation of side-chain interactions and conformational equilibria. Its balanced architecture allows high-resolution biophysical evaluation.
CAT No: R2331
CAS No:2166487-23-4
Synonyms/Alias:Et-29;2166487-23-4;AKOS040754595;MS-31041;HY-145651;CS-0377508;ethyl 3-[[(5S)-6-[[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(propan-2-ylamino)propan-2-yl]amino]-6-oxo-5-(phenylmethoxycarbonylamino)hexyl]carbamothioylamino]propanoate;
Et-29 is a synthetic carbohydrate compound renowned for its unique structural properties and versatility in biochemical research. Characterized by a stable glycosidic linkage and a hydrophilic profile, Et-29 integrates seamlessly into a variety of experimental systems, enabling researchers to explore carbohydrate-mediated interactions with high specificity. Its solubility and compatibility with aqueous solutions make it a preferred choice for in vitro studies, while its defined structure allows for reproducible results across different research applications. The compound's adaptability extends to conjugation protocols, facilitating its incorporation into more complex molecular assemblies for advanced analytical or functional studies.
Glycobiology research: In the field of glycobiology, Et-29 serves as a valuable tool for elucidating the roles of carbohydrate moieties in cellular communication and molecular recognition. Scientists employ this compound to investigate glycan-binding proteins, such as lectins, and to map carbohydrate-mediated signaling pathways. By introducing Et-29 into binding assays or cell culture systems, researchers can dissect the specificity and affinity of carbohydrate-protein interactions, advancing our understanding of cell adhesion, migration, and immune modulation. This approach is instrumental in identifying novel glycan receptors and characterizing their biological functions.
Analytical chemistry: Analytical chemists utilize Et-29 as a reference standard or derivatization agent in chromatographic and spectrometric techniques. Its well-defined structure allows for the calibration of analytical instruments, ensuring accurate quantification and identification of related carbohydrate species in complex mixtures. In mass spectrometry, Et-29 can be conjugated to target analytes, enhancing their ionization efficiency and improving detection sensitivity. Such applications are critical in glycomics for profiling oligosaccharide compositions and monitoring post-translational modifications on proteins.
Drug discovery and design: Within drug discovery pipelines, Et-29 is leveraged as a scaffold for the synthesis of glycomimetic compounds. Medicinal chemists exploit its carbohydrate backbone to design molecules that mimic the biological activity of native glycans, thereby modulating protein-carbohydrate interactions implicated in disease pathways. The compound's stability and functional group compatibility enable the generation of diverse analogues, facilitating structure-activity relationship studies. These efforts contribute to the identification of lead compounds with enhanced selectivity and potency for therapeutic targets.
Biomaterials development: In biomaterials science, Et-29 is incorporated into polymeric matrices, hydrogels, or surface coatings to impart bioactive carbohydrate functionalities. The presence of this synthetic glycan enhances cell-material interactions, promoting cell adhesion, proliferation, and differentiation in tissue engineering applications. Researchers also exploit its hydrophilic nature to modulate the physicochemical properties of biomaterials, such as wettability and biocompatibility. By tailoring the presentation of Et-29 on material surfaces, scientists can direct cellular responses and improve the performance of biomedical devices.
Enzymology studies: Et-29 is frequently employed as a substrate or inhibitor in enzymology research focused on carbohydrate-active enzymes. Its defined structure makes it suitable for kinetic assays, enabling the characterization of enzyme specificity, catalytic efficiency, and inhibition mechanisms. By monitoring the enzymatic conversion of Et-29 or its analogues, researchers gain insights into the molecular determinants of glycosidase and glycosyltransferase activity. These studies are pivotal for understanding carbohydrate metabolism and for developing enzyme modulators with potential applications in biotechnology.
Biophysical analysis: The application of Et-29 extends to biophysical techniques, where it is used to probe the thermodynamics and kinetics of carbohydrate interactions. Surface plasmon resonance, isothermal titration calorimetry, and nuclear magnetic resonance spectroscopy are among the methods that benefit from the inclusion of this compound. By providing a consistent and well-characterized glycan ligand, Et-29 enables high-resolution analysis of binding events, conformational changes, and molecular dynamics. Such investigations deepen our knowledge of carbohydrate recognition processes and support the rational design of glycan-based probes and sensors.
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at . We will endeavor to provide highly satisfying products and services.
Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
Read More