Et-29 is a synthetic peptide analog containing alternating polar, hydrophobic, and aromatic residues that influence secondary-structure formation. Researchers employ it to explore solvent-dependent folding, β-turn stability, and ligand-recognition behavior. The motif supports investigation of side-chain interactions and conformational equilibria. Its balanced architecture allows high-resolution biophysical evaluation.
CAT No: R2331
CAS No:2166487-23-4
Synonyms/Alias:Et-29;2166487-23-4;AKOS040754595;MS-31041;HY-145651;CS-0377508;ethyl 3-[[(5S)-6-[[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(propan-2-ylamino)propan-2-yl]amino]-6-oxo-5-(phenylmethoxycarbonylamino)hexyl]carbamothioylamino]propanoate;
Et-29 is a synthetic peptide compound characterized by its unique sequence and structural features, making it a valuable tool in biochemical and molecular biology research. As a member of the peptide class, it is engineered to investigate specific protein interactions, receptor binding dynamics, and functional modulation within various biological systems. The design and versatility of Et-29 allow researchers to explore mechanistic pathways and cellular responses with precision, supporting advanced studies in signal transduction, enzyme activity, and regulatory processes. Its robust utility in experimental protocols underscores its significance in the expanding field of peptide-based research.
Peptide interaction studies: Et-29 is frequently employed to probe protein-protein and protein-ligand interactions, offering a controlled means to elucidate binding affinities and specificity in vitro. Researchers utilize this peptide to map interaction domains, assess competitive inhibition, and dissect molecular recognition events central to cellular signaling. The defined sequence of Et-29 enables systematic mutational analyses, facilitating the identification of critical residues involved in functional complexes and advancing the understanding of complex biochemical networks.
Receptor binding assays: The compound serves as an effective ligand in receptor characterization experiments, providing insights into receptor specificity and activation mechanisms. By incorporating Et-29 into binding assays, scientists can quantify receptor-ligand interactions, determine dissociation constants, and evaluate the effects of structural modifications on receptor engagement. Such studies are instrumental in deciphering the molecular determinants of signal transduction and in supporting the development of novel modulators for research applications.
Peptide synthesis optimization: Et-29 is utilized as a model peptide in the optimization of solid-phase peptide synthesis protocols. Its defined sequence and physicochemical properties make it suitable for benchmarking coupling efficiency, resin compatibility, and purification strategies. Laboratories engaged in peptide production leverage Et-29 to assess the impact of synthesis parameters, troubleshoot common bottlenecks, and refine methodologies for the generation of high-quality peptides, thereby improving overall workflow reliability and reproducibility.
Functional cell-based assays: In cell biology, Et-29 is incorporated into functional assays to investigate its influence on cellular processes such as proliferation, differentiation, and signal modulation. Researchers introduce the peptide to cultured cells to monitor downstream effects, enabling the delineation of pathway-specific responses and the identification of potential modulatory roles. These applications are particularly valuable for dissecting complex intracellular signaling cascades and for validating the biological relevance of peptide-mediated interventions.
Analytical method development: The well-defined properties of Et-29 make it a reliable standard in the development and validation of analytical techniques, including high-performance liquid chromatography (HPLC) and mass spectrometry. Analytical laboratories utilize the peptide to calibrate instrumentation, establish detection limits, and verify method accuracy for peptide quantification. Its consistent performance in these contexts supports rigorous quality control and ensures the reproducibility of analytical workflows across diverse research settings.
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